Lista de reconhecimentos e fontes de financiamento. O trabalho é apoiado pelo NIH RO1-MH54246 (MB), Fundação Nacional de Ciência BCS0923763 (MB), da Defense Advanced Research Projects Agency (DARPA), sob contrato NBCHZ090439 (WS), o Office of Naval Research (ONR) sob prêmio N00014-11 -1-0399 (WS), e do Exército Research Lab (ARL), sob contrato W911NF-10-2-0022 (WS). Os pontos de vista, opiniões e / ou resultados contidas nesta apresentação são de responsabilidade dos autores e não deve ser interpretada como representando a posição oficial ou políticas, expressas ou implícitas, das agências acima ou os Estados Unidos Departamento de Defesa.

<ol>
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High-resolution DWI e tratografia fibra proporcionar uma abordagem poderosa para a análise da estrutura conjuntivo do cérebro humano. Aqui, apresentamos evidências de que esta arquitetura estrutural é significativamente relacionados com a função cerebral, avaliada por fMRI. Usando sementes tratografia baseados na ativação tarefa fMRI, encontramos evidências de que as áreas do cérebro que são co-ativo durante atenção visual são anatomicamente connectedconsistent com conhecimento prévio da neuroanatomia fu...

co-analysis of brain structure and function using fmri and diffusion-weighted imaging

O estudo de complexos sistemas computacionais é facilitada por mapas de rede, tais como diagramas de circuitos. Tal mapeamento é particularmente informativo quando se estuda o cérebro, como o papel funcional que cumpre uma área do cérebro pode ser em grande parte definidos por suas conexões com outras áreas do cérebro. Neste relatório, nós descrevemos um romance, a abordagem não-invasiva para relacionar a estrutura e função do cérebro usando ressonância magnética (MRI). Esta abordagem, de uma combinação de ligações de imagem estrutural de longo alcance e dados de imagem de fibras funcionais, é ilustrado em duas distintas cognitivas, atenção visual e percepção face. Imagem estrutural é realizada com imagem ponderada em difusão (DWI) e tratografia fibra, que controlar a difusão de moléculas de água ao longo de extensões de fibra de substância branca do cérebro (Figura 1). Ao visualizar estes feixes de fibras, que são capazes de investigar a arquitetura de longo alcance conectivo do cérebro. Os resultados de comparação favoraBly com uma das técnicas mais utilizadas em DWI, tensor de difusão de imagem (DTI). DTI é incapaz de resolver complexas configurações de feixes de fibras, limitando a sua utilidade para a construção de modelos detalhados, anatomicamente informadas da função cerebral. Em contraste, as nossas análises reproduzir neuroanatomia conhecido com precisão e exatidão. Esta vantagem é em parte devido a procedimentos de aquisição de dados: enquanto muitos DTI difusão medida protocolos em um pequeno número de instruções (por exemplo, 6 ou 12), que empregam uma difusão espectro de imagem (DSI) 1, 2 protocolo que avalia a difusão em 257 direções e em uma série de pontos fortes gradientes magnéticos. Além disso, dados da DSI nos permite utilizar métodos mais sofisticados para reconstruir dados adquiridos. Em dois experimentos (atenção visual ea percepção de face), tratografia revela que as áreas de co-ativas do cérebro humano são anatomicamente ligados, apoiando hipóteses existentes que formam redes funcionais. DWI nos permite criar um &quot;circuito de diagram &quot;e reproduzi-lo em uma base individual-sujeito, com o objetivo de monitoramento da atividade cerebral em tarefas relevantes em redes de interesse.

Watch this Scientific Journal Video about Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging at JoVE.com

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Nós descrevemos uma nova abordagem para a análise simultânea da função cerebral e estrutura usando ressonância magnética (MRI). Avaliamos a estrutura do cérebro com imagens ponderada em difusão de alta resolução e de matéria-branco tratografia fibra. Ao contrário do padrão estrutural de ressonância magnética, estas técnicas permitem-nos relacionar diretamente conectividade anatômica a propriedades funcionais de redes cerebrais.

Co-análise de estrutura e função cerebral usando ressonância magnética funcional e imagem ponderada em difusão

The study of complex computational systems is facilitated by network maps, such as circuit diagrams. Such mapping is particularly informative when ...

co-analysis-brain-structure-function-using-fmri-diffusion-weighted

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26.0K visualizações.  Center for the Neural Basis of Cognition. Nós descrevemos uma nova abordagem para a análise simultânea da função cerebral e estrutura usando ressonância magnética (MRI). Avaliamos a estrutura do cérebro com imagens ponderada em difusão de alta resolução e de matéria-branco tratografia fibra. Ao contrário do padrão estrutural de ressonância magnética, estas técnicas permitem-nos relacionar diretamente conectividade anatômica a propriedades funcionais de redes cerebrais.