Subretinal Injection of Sodium Iodate into a Large-eyed Animal Model
4:36
Subretinal Transplantation of hESC-RPE Cells in Treated Animals
7:35
In Vivo Retinal and Subretinal Imaging
8:47
Results: Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells
10:22
Conclusion
TRANSCRIÇÃO
The overall goal of this procedure is to create a large-eyed animal model of geographic atrophy to transplant human embryonic derived-retinal pigment epithelial cells into the eye and assess donor cell integration using optical coherence tomograph
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Retinal pigment epithelial cells could serve as a cell-replacement therapy for the advanced form of dry age-related macular degeneration. This protocol describes the generation of a large-eyed model of geographic atrophy and the subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelial cells into this model of disease.