permanent-ligation-left-anterior-descending-coronary-artery-mice

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Heart failure is a syndrome in which the heart fails to pump blood at a rate commensurate with cellular oxygen requirements at rest or during stress. It ...

in-vitro-vivo-model-to-study-bacterial-adhesion-to-vessel-wall-under

<em>In Vitro</em> and <em>In Vivo</em> Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

In order to cause endovascular infections and infective endocarditis, bacteria need to be able to adhere to the vessel wall while being exposed to the ...

Catholic University of Leuven

KU Leuven

To assess the effect of hypercholesterolemia on neointima formation and vascular remodelling after porcine coronary angioplasty.

Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty.

Ischemic preconditioning (IP) describes the adaptation of the myocardium to ischemic stress preceded by short periods of ischemia and reperfusion. However, its cardioprotective mechanisms are not completely understood. We assessed the effect of IP on ventricular energetics in an in-vivo sheep model.

Ischemic preconditioning reduces unloaded myocardial oxygen consumption in an in-vivo sheep model.

Hypercholesterolemia induces functional and structural changes of the microvasculature and reduces coronary flow reserve in humans and experimental animals. The effect of hypercholesterolemia on left ventricular (LV) function in the absence of coronary stenosis is, however, unknown. Our objective was therefore to assess the effect of hypercholesterolemia and cholesterol withdrawal on LV function in the presence of advanced coronary plaques that do not cause stenosis.

Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary density.

Cardiac arrest and cardiopulmonary resuscitation may result in multiorgan damage after global hypoxia due to neutrophil recruitment. Patients display all signs of a systemic inflammatory response syndrome. Reducing neutrophil recruitment may thus preserve organ function.

Marleen Lox

Department of Cardiovascular Sciences,
Centre for Molecular and Vascular Biology,
Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology

Catholic University of Leuven

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

Marleen Lox

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Cardiovascular Sciences,Centre for Molecular and Vascular Biology,Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology

Catholic University of Leuven

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

Department of Cardiovascular Sciences,
Centre for Molecular and Vascular Biology,
Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology