Mike Grotewiel

Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed.

Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants.

A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment.

Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age-related parameters in Drosophila.

Sod2 knockdown in the musculature has whole-organism consequences in Drosophila.

An assay for evoked locomotor behavior in Drosophila reveals a role for integrins in ethanol sensitivity and rapid ethanol tolerance.

Drosophila as a model for age-related impairment in locomotor and other behaviors.

Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans.

Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease.

Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays.

Paraquat exposure and Sod2 knockdown have dissimilar impacts on the Drosophila melanogaster carbonylated protein proteome.