utilizing-functional-genomics-screening-to-identify-potentially-novel

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

The identification of functional driver events in cancer is central to furthering our understanding of cancer biology and indispensable for the discovery ...

The Institute of Cancer Research

Dual antiplatelet therapy with clopidogrel and aspirin has been shown to reduce recurrent cardiac events in patients with acute coronary syndromes or those who have undergone coronary artery stent placement. Clopidogrel, a thienopyridine, is a prodrug that is transformed in vivo to an active metabolite by the cytochrome P450 enzyme system. Due to the increased risk of bleeding in patients on dual antiplatelet therapy, concomitant gastrointestinal ulcer prophylaxis with a proton pump inhibitor (PPI) is frequently prescribed. Data from recent studies show that PPIs, which are extensively metabolized by the cytochrome system, may decrease the antiplatelet activity of clopidogrel. This article reviews the metabolism of various PPIs and existing data regarding the drug-drug interaction between PPIs and clopidogrel.

Drug interaction between clopidogrel and proton pump inhibitors.

Targeted therapies are being used as maintenance therapy to improve the outcome of ovarian cancer following standard treatment in the first-line setting and in recurrent disease. We review the different approaches being used, trial design, and the impact of maintenance treatment on survival and quality of life.

Saira Khalique

The Breast Cancer Now Toby Robins Research Centre,
Division of Breast Cancer,
Division of Molecular Pathology,
The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer

The Institute of Cancer Research

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Saira Khalique

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}The Breast Cancer Now Toby Robins Research Centre,Division of Breast Cancer,Division of Molecular Pathology,The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer

The Institute of Cancer Research

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

The Breast Cancer Now Toby Robins Research Centre,
Division of Breast Cancer,
Division of Molecular Pathology,
The Breast Cancer Now Toby Robins Research Centre, Division of Breast Cancer