remotely-supervised-transcranial-direct-current-stimulation-an-update

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

The remotely supervised tDCS (RS-tDCS) protocol enables participation from home through guided and monitored self-administration of tDCS treatment while ...

Langone Medical Center

CBMs (carbohydrate-binding modules) are a class of polypeptides usually associated with carbohydrate-active enzymatic sites. We have characterized a new member of the CBM40 family, coded from a section of the gene NanI from Clostridium perfringens Glycan arrays revealed its preference towards α(2,3)-linked sialosides, which was confirmed and quantified by calorimetric studies. The CBM40 binds to α(2,3)-sialyl-lactose with a Kd of ∼30 μM, the highest affinity value for this class of proteins. Inspired by lectins' structure and their arrangement as multimeric proteins, we have engineered a dimeric form of the CBM, and using SPR (surface plasmon resonance) we have observed 6-11-fold binding increases due to the avidity affect. The structures of the CBM, resolved by X-ray crystallography, in complex with α(2,3)- or α(2,6)-sialyl-lactose explain its binding specificity and unusually strong binding.

William Pau

New York University

Langone Medical Center

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

William Pau

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}New York University

Langone Medical Center

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

New York University