Shimin Le

Force and ATP hydrolysis dependent regulation of RecA nucleoprotein filament by single-stranded DNA binding protein.

Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry.

Dynamics and Regulation of RecA Polymerization and De-Polymerization on Double-Stranded DNA.

Mechanosensing of DNA bending in a single specific protein-DNA complex.

Mechanical force antagonizes the inhibitory effects of RecX on RecA filament formation in Mycobacterium tuberculosis.

Mechanochemical regulations of RPA's binding to ssDNA.

Disturbance-free rapid solution exchange for magnetic tweezers single-molecule studies.

Uncovering mechanosensing mechanisms at the single protein level using magnetic tweezers.

Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains.