cost-efficient-transcriptomic-based-drug-screening

Cost-Efficient Transcriptomic-Based Drug Screening

Transcriptomics allows&#160;to obtain comprehensive insights into cellular programs and their responses to perturbations. Despite a significant decrease ...

German Center for Neurodegenerative Diseases (DZNE) eV.

University of Bonn

Variance of gene expression is intrinsic to any given natural population. Here, we present a protocol to analyze this variance using a conditional quasi loss- and gain-of-function approach. The huva (human variation) package takes advantage of population-scale multi-omics data to infer gene function and the relationship between phenotype and gene expression. We describe the steps for setting up the huva workspace, formatting datasets, performing huva experiments, and exporting data. For complete details on the use and execution of this protocol, please refer to Bonaguro et al. (2022)..

Lorenzo Bonaguro

Systems Medicine

German Center for Neurodegenerative Diseases (DZNE) eV.

Cost-Efficient Transcriptomic-Based Drug Screening

Lorenzo Bonaguro

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German Center for Neurodegenerative Diseases (DZNE) eV.

Cost-Efficient Transcriptomic-Based Drug Screening

Systems Medicine