whole-mount-immunostaining-automatic-counting-mouse-retinal-ganglion

Whole-Mount Immunostaining and Automatic Counting of Mouse Retinal Ganglion Cells

Glaucoma is a leading cause of blindness globally, characterized by a complex pathogenic mechanism that makes vision restoration challenging. Mice serve ...

University of Electronic Science and Technology of China

Vaccinations are essential for preventing and treating disease, especially cancer nanovaccines, which have gained considerable interest recently for their strong anti-tumor immune capabilities. Vaccines can prompt the immune system to generate antibodies and activate various immune cells, leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and surgery. To enhance the flexibility and targeting of vaccines, nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level, enabling more controlled and precise drug delivery to enhance immune responses. Cancer nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within nanomaterials. The small size of these nanomaterials allows for precise targeting of T cells, dendritic cells, or cancer cells, thereby eliciting a more potent anti-tumor response. In this paper, we focus on the classification of carriers for cancer nanovaccines, the roles of different target cells, and clinically tested cancer nanovaccines, discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation, while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

Congrui Liu

Sichuan Provincial Key Laboratory for Human Disease Gene Study,
Sichuan Provincial People's Hospital,
Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital

University of Electronic Science and Technology of China

Whole-Mount Immunostaining and Automatic Counting of Mouse Retinal Ganglion Cells

Congrui Liu

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University of Electronic Science and Technology of China

Whole-Mount Immunostaining and Automatic Counting of Mouse Retinal Ganglion Cells

Sichuan Provincial Key Laboratory for Human Disease Gene Study,
Sichuan Provincial People's Hospital,
Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital