Pierre Dourlen

The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease.

Pin1 allows for differential Tau dephosphorylation in neuronal cells.

ER stress protects from retinal degeneration.

Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila.

ER stress inhibits neuronal death by promoting autophagy.

Drosophila models of tauopathies: what have we learned?

Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila.