Laboratory of Structural Biology
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The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase kappa.
Biochemistry May, 2009 | Pubmed ID: 19341290
Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.
Nucleic acids research Jan, 2010 | Pubmed ID: 19939936
Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa.
Mutation research Jan, 2011 | Pubmed ID: 21078407
Mutational specificities of brominated DNA adducts catalyzed by human DNA polymerases.
Journal of molecular biology Mar, 2011 | Pubmed ID: 21241706
DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22989888
Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases.
Mutagenesis Jan, 2013 | Pubmed ID: 23076070
NIEHS, National Institutes of Health
Akira Sassa1,
William A. Beard1,
David D. Shock1,
Samuel H. Wilson1
1Laboratory of Structural Biology, NIEHS, National Institutes of Health
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