The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.

Vitamin A

Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.

Vitamin B12

Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role in iron metabolism, which is involved in bone formation.

Vitamin C

Vitamin C is a cofactor for enzymes required to maintain a stable triple-helical conformation of collagen. Also, vitamin C stimulates the activity of the enzyme alkaline phosphatase. This enzyme is a marker for osteoblast formation and helps in bone mineralization.

Vitamin D

Calcium cannot be absorbed from the small intestine without vitamin D. Insufficiency of vitamin D is therefore linked to osteoporosis, which can be associated with an increased risk of fractures.

Vitamin K

Vitamin K is necessary for the γ-carboxylation of osteocalcin, the principal non-collagenous protein of bone. Specifically, vitamin K is a cofactor of γ -carboxylase, an enzyme involved in γ -carboxylation of glutamic acid residues in proteins, including osteocalcin. Carboxylated osteocalcin helps in the mineralization of the bone matrix.

This text is adapted from Openstax, Anatomy and Physiology 2e, Section 6.6: Exercise, Nutrition, Hormones, and Bone Tissue.

Теги
VitaminsBone HealthVitamin AVitamin B12Vitamin CVitamin DVitamin KBone RemodelingOsteoblastsOsteoclastsOsteocalcinCollagenMineralizationOsteoporosis

Из главы 10:

article

Now Playing

10.17 : Role of Vitamins in Maintaining Bone Health

Bone Tissue and the Skeletal System

3.0K Просмотры

article

10.1 : Введение в костную систему

Bone Tissue and the Skeletal System

4.5K Просмотры

article

10.2 : Функции костной системы

Bone Tissue and the Skeletal System

3.1K Просмотры

article

10.3 : Классификация костей

Bone Tissue and the Skeletal System

4.4K Просмотры

article

10.4 : Общая анатомия кости

Bone Tissue and the Skeletal System

4.3K Просмотры

article

10.5 : Компактная кость

Bone Tissue and the Skeletal System

10.4K Просмотры

article

10.6 : Губчатая кость

Bone Tissue and the Skeletal System

3.7K Просмотры

article

10.7 : Костяные отметины

Bone Tissue and the Skeletal System

4.8K Просмотры

article

10.8 : Костные клетки и ткани

Bone Tissue and the Skeletal System

3.9K Просмотры

article

10.9 : Костный матрикс

Bone Tissue and the Skeletal System

2.7K Просмотры

article

10.10 : Кровоснабжение и нервное снабжение костей

Bone Tissue and the Skeletal System

9.9K Просмотры

article

10.11 : Костеобразование путем внутримембранозной оссификации

Bone Tissue and the Skeletal System

4.6K Просмотры

article

10.12 : Формирование костной ткани путем эндохондрального окостенения

Bone Tissue and the Skeletal System

3.0K Просмотры

article

10.13 : Ремоделирование и восстановление костей

Bone Tissue and the Skeletal System

4.2K Просмотры

article

10.14 : Переломы: восстановление костей

Bone Tissue and the Skeletal System

2.7K Просмотры

See More

JoVE Logo

Исследования

Образование

О JoVE

Авторские права © 2025 MyJoVE Corporation. Все права защищены