In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral and intravenous administration.
By integrating solubility and permeability, the Biopharmaceutical Classification System highlights how transporters influence drug disposition; for instance, Class II drugs face significant challenges due to efflux into the gastrointestinal lumen and biliary excretion.
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