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Chapter 24

Drugs for Nausea and Vomiting

Pathophysiology of Vomiting
Pathophysiology of Vomiting
Vomiting, or emesis, is a protective reflex that forcefully expels stomach content due to triggers like medication, pregnancy, GI disorders or infections, ...
Chemotherapy-Induced Nausea and Vomiting: 5-HT<sub>3</sub> Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Vomiting is a common side effect among individuals undergoing chemo and radiation therapy. In these patients, the damaged GI mucosa releases serotonin, ...
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
The central vomiting center and the chemoreceptor trigger zone in the brainstem are rich in neurokinin 1 or NK1 receptors. During chemotherapy, the GI ...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Vomiting is a distressing symptom often triggered by cancer chemotherapy. Dopamine receptor antagonists are key antiemetics. They bind to dopamine ...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Vomiting, a protective reflex to expel toxins from the gut, can become a distressing side effect of regular chemotherapy. Neurons near the chemoreceptor ...
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