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Chapter 14

Biostatistics

Overview of Biostatistics in Health Sciences
Overview of Biostatistics in Health Sciences
Biostatistics involves applying statistical concepts to health-related fields such as public health and epidemiology, often with human subjects. This ...
Introduction to Epidemiology
Introduction to Epidemiology
Epidemiology studies the patterns, distributions, and factors determining diseases and health conditions in a target population. Its methodology varies ...
Prevalence and Incidence
Prevalence and Incidence
In epidemiology, prevalence refers to the probability of people being affected by a disease in a target population. Conversely, incidence is the ...
Sensitivity, Specificity, and Predicted Value
Sensitivity, Specificity, and Predicted Value
In health sciences, sensitivity refers to the probability that a diagnostic test shows a positive result when the disease is present. On the other hand, ...
Receiver Operating Characteristic Plot
Receiver Operating Characteristic Plot
When assessing a diagnostic tool or test for a particular illness, it's crucial to weigh the significance of both sensitivity and specificity. A ...
Study Designs in Epidemiology
Study Designs in Epidemiology
Consider an example of testing calcium's effect on a woman's bone weight. In an ideal study design, the same woman would be observed in two ...
Response Surface Methodology
Response Surface Methodology
Response Surface Methodology, or RSM, is a statistical technique that analyzes several input variables or factors potentially influencing a response ...
Relative Risk
Relative Risk
Relative risk, or risk ratio, is the ratio of the probability of a disease occurring in the exposed group to the probability in the unexposed or control ...
Odds Ratio
Odds Ratio
The odds ratio, or cross-product ratio, is the ratio of the odds that a disease occurs upon exposure to a risk factor to the odds that the same disease ...
Causality in Epidemiology
Causality in Epidemiology
Causality, or causation, is fundamentally different from a correlation. Consider a hypothetical correlation between the number of hospitals in a region ...
Confounding in Epidemiological Studies
Confounding in Epidemiological Studies
Confounding refers to the distortion of the estimated association between an exposure and an outcome due to the influence of a third variable, known as a ...
Strategies for Assessing and Addressing Confounding
Strategies for Assessing and Addressing Confounding
Confounding affects conclusions about the associations between exposures and outcomes. But, it can be addressed during both the design and analysis ...
Criteria for Causality: Bradford Hill Criteria - I
Criteria for Causality: Bradford Hill Criteria - I
Sir Austin Bradford Hill suggested nine criteria for causality, out of which strength, consistency, specificity, and temporality are explained here. The ...
Criteria for Causality: Bradford Hill Criteria - II
Criteria for Causality: Bradford Hill Criteria - II
The Bradford Hill criteria for causality include biological gradient, plausibility, coherence, experiment, and analogy. The biological gradient, or ...
Bias in Epidemiological Studies
Bias in Epidemiological Studies
A bias is a systematic tendency of a quantity's estimate or expected value to be skewed or far from the true value. For example, a thermometer ...
Statistical Methods for Analyzing Epidemiological Data
Statistical Methods for Analyzing Epidemiological Data
Various statistical techniques are used to analyze epidemiological data and guide appropriate public health interventions. Consider a study on the ...
Steps in Outbreak Investigation
Steps in Outbreak Investigation
An outbreak occurs when disease cases unexpectedly exceed normal levels in a specific area and timeframe, such as when multiple people contract a similar ...
Principles of Disease Surveillance
Principles of Disease Surveillance
Disease surveillance involves systematic data collection and analysis, which is essential for public health management and disease prevention. ...
Longitudinal Studies
Longitudinal Studies
Longitudinal studies are research designs involving repeated observation of the same subjects, capturing changes and developments over time. These studies ...
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