Name: Inflammatory Response I: Vascular and Cellular
Uploaded: 2023-12-28T10:51:28
Description: Learn by watching this video about Inflammatory Response I: Vascular and Cellular at JoVE.com

The inflammatory response is a defense mechanism of the body against infection, injury, or irritation.
It can be acute, lasting days or weeks, or chronic, lasting several months to years.
Inflammation helps identify and destroy pathogens and removes damaged tissue elements so the body can heal.
This response is seen at the vascular and cellular levels. Both are crucial components of the acute inflammatory process.
At the vascular stage, small blood vessels near the injury site initially constrict to prevent blood loss.
The arterioles and venules supplying blood to that area dilate, increasing blood flow and causing local redness and heat.
In addition, the release of cell mediators, such as histamine, bradykinin, and prostaglandins, in the injured area increases vascular permeability to protein- and immune-cell-rich fluids, which causes swelling, pain and loss of function.
During the cellular stage, white blood cells, or WBCs, pass through the blood vessels and rush to the site of injury, causing an increase in the overall WBC count.
WBCs, like neutrophils and monocytes, engulf pathogens and ingest cell debris and foreign material. As a result of pathogen phagocytosis, pyrogens are released, causing fever.

inflammatory response i: vascular and cellular

The inflammatory response is the body&#39;s defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea, vomiting, lymph node enlargement, or organ failure.
The crucial components of the inflammatory process are the vascular and cellular stages. At the vascular stage, small blood vessels constrict initially; then, the arterioles and venules that supply the area dilate, increasing the blood flow and causing redness and heat. In addition, the release of cell mediators, such as histamine, increases vascular permeability and allows protein-rich fluids to flow into the area, which can cause swelling, pain, and loss of function. During the cellular stage, white blood cells rush into the area. Neutrophils and monocytes engulf pathogens through phagocytosis and ingest cell debris and foreign material. This leads to the phagocytic release of pyrogens from bacterial cells, causing fever.

Learn by watching this video about Inflammatory Response I: Vascular and Cellular at JoVE.com

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body&#39;s defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps ...