Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal dryness, insomnia, depression, weight gain, and mood swings.

Postmenopausal women may also experience atrophy of reproductive organs and breasts. A significant concern is the decline in bone mineral density, which increases the risk of osteoporosis due to reduced estrogen levels. Sexual desire in postmenopausal women can vary; while it may decline for some due to hormonal changes, it may be maintained in part by adrenal androgens and psychosocial factors.

The risk of uterine (endometrial) cancer peaks between the ages of 60 and 70, while cervical cancer is most prevalent in women aged 35 to 44.

On the other hand, males experience a more gradual decline in reproductive function. Many retain their reproductive capacity well into old age. However, around the age of 55, a decrease in testosterone synthesis can lead to reduced muscle strength, fewer viable sperm, and decreased sexual desire. Although sperm production declines significantly between the ages of 60 and 80, viable sperm may still be present in substantial quantities.

A common condition in men over 60 is benign prostatic hyperplasia (BPH), an enlargement of the prostate gland that compresses the prostatic urethra, leading to urinary symptoms such as frequent urination, weak urine flow, and difficulty emptying the bladder.