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Mouse Echocardiography: A Non-invasive Technique to Assess Cardiac Morphology
Overview
This video describes a protocol to perform echocardiography on a laboratory mouse.
Protocol
All procedures involving animal models have been reviewed by the local institutional animal care committee and the JoVE veterinary review board.
1. Echocardiography
- Determine the body weight of the mouse using a standard laboratory balance while holding it lightly by the tail to ensure proper positioning.
- Anesthetize the animal by the intraperitoneal (i.p.) injection of 50 mg/kg pentobarbital.
NOTE: Any other kind of anesthesia can be used if the same protocol is used throughout the study. Advantages and disadvantages will be discussed below. - Put the mouse back in its ....
Representative Results
Figure 1: Standard-resolution echocardiography (>10 MHz) to measure LV systolic and diastolic dimensions and cardiac function in mice with dilated cardiac hypertrophy after myocardial infarction versus control animals. Representative echocardiographic recordings from normal, healthy mice (A) and animals with LV dilation and reduced LV function after myoca.......
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Source: Baudouy, D., et al. Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse. J. Vis. Exp. (2017).
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