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Generating a Rabbit Calvarial Defect Model: A Surgical Procedure to Create Round Defects in the Top Portion of the Rabbit Skull to Assess Bone Substitute Materials for Bone Regeneration Capacities
Overview
In this video, we describe the surgical procedure to generate a rabbit calvarial model to evaluate the bone regeneration capacities of bone sample substitution materials of interest.
Protocol
All procedures involving animal models have been reviewed by the local institutional animal care committee and the JoVE veterinary review board.
1. Surgery
- Site preparation
- Place the rabbit on a heated pad (39 °C) covered by a mattress pad (to avoid burns) on the surgery table. Shave the scalp.
- Apply a lubricating gel on the eyes to avoid irritation and dryness. Disinfect the site by scrubbing the skin with povidone iodine (10%). Then dr.......
Representative Results
Figure 1: Specifications of PEEK cylinders. Two holes (0.8 mm in diameter) were drilled on the lateral stabilizing tabs for screwing. The positions of the 5 intramedullary holes (0.8 mm in diameter) to be drilled on the skull within the area delimited by the cylinder are marked using red circles.
This article has been published
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Source: Marger, L. et al., Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials. J. Vis. Exp. (2019).
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