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Encyclopedia of Experiments

A Technique for Magnetic Glass Particle-Mediated Nucleic Acid Extraction from Blood

This video demonstrates a technique for nucleic acid extraction from whole human blood using magnetic glass particles (MGPs) — small magnetic beads coated with silica. Upon lysing the blood cells using a lysis buffer, the released nucleic acids bind to the surface of silica-coated MGPs, extracting the molecules from the sample.

All procedures involving sample collection have been performed in accordance with the institute's IRB guidelines

1. Blood Collection from Patients

CAUTION: Take appropriate laboratory safety measures when collecting whole blood from the patient. Wear gloves and glasses. If the patient is in isolation, please follow biosafety level 4 procedures.

  1. To collect intravenous whole blood from the patient, use a butterfly need.......

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