Xiaohong Zhu

Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.

The bifunctional LKR/SDH locus of plants also encodes a highly active monofunctional lysine-ketoglutarate reductase using a polyadenylation signal located within an intron.

Impact of preimmunization on adenoviral vector expression and toxicity in a subcutaneous mouse cancer model.

The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains.

Renal principal cell-specific expression of green fluorescent protein in transgenic mice.

Increased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds.

Effects on telomerase activity and associated-protein of hRPE cells by TGF-beta 1.

Lysine metabolism is concurrently regulated by synthesis and catabolism in both reproductive and vegetative tissues.

Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development.

Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla.

Application of tetrahydrofuran dispersant in microemulsion for fabricating titania mesoporous thin film.

Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors.

Novel nitrite sensing using a palladium-polyphenosafranine nano-composite.

Multiple condylomata lata: a case report.

Virus-induced gene silencing as a tool to identify host genes affecting viral pathogenicity.

Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands.

Isolation, structural determination, synthesis and quantitative determination of impurities in Intron-A, leached from a silicone tubing.

Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.

Deciphering transcriptional and metabolic networks associated with lysine metabolism during Arabidopsis seed development.

Induced ER chaperones regulate a receptor-like kinase to mediate antiviral innate immune response in plants.

Function of endoplasmic reticulum calcium ATPase in innate immunity-mediated programmed cell death.

Virus-induced gene silencing offers a functional genomics platform for studying plant cell wall formation.

SGT1 positively regulates the process of plant cell death during both compatible and incompatible plant-pathogen interactions.

ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method.

Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.

A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.

SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist.

Co-effect of insulin resistance and biomarkers of inflammation and endothelial dysfunction on hypertension.

Nebulizing conditions of pneumatic electrospray ionization significantly influence electrolyte effects on compound measurement.

A histone acetyltransferase regulates active DNA demethylation in Arabidopsis.

The formation of percolative composites with a high dielectric constant and high conductivity.

Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature.

Myocardin regulates BMP10 expression and is required for heart development.

Aequorin-based luminescence imaging reveals stimulus- and tissue-specific Ca2+ dynamics in Arabidopsis plants.

[Histological study of dual factor inducing axial vascularization in double-layered scaffold].

Double repression in jasmonate-mediated plant defense.

Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties.

An Rrp6-like protein positively regulates noncoding RNA levels and DNA methylation in Arabidopsis.

A novel molecularly imprinted material based on magnetic halloysite nanotubes for rapid enrichment of 2,4-dichlorophenoxyacetic acid in water.

The ABA receptor PYL8 promotes lateral root growth by enhancing MYB77-dependent transcription of auxin-responsive genes.

The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators.

Discovery of a potent nicotinic Acid receptor agonist for the treatment of dyslipidemia.

Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia.

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease.

Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.

Regulation of Active DNA Demethylation by an α-Crystallin Domain Protein in Arabidopsis.