Ruth S. Slack

The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.

Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.

The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.

Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death.

Caspase 3 activity is required for skeletal muscle differentiation.

Calpains mediate p53 activation and neuronal death evoked by DNA damage.

Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

Growth factors: can they promote neurogenesis?

Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.

Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

Role of AIF in caspase-dependent and caspase-independent cell death.

The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.

Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.

p107 regulates neural precursor cells in the mammalian brain.

Emerging role for ERK as a key regulator of neuronal apoptosis.

p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death.

c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.

The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.

Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.

Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.

Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.

A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration.

Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.

Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.

Novel functions for cell cycle genes in nervous system development.

Urine concentrating defect in prostaglandin EP1-deficient mice.

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.

The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.

Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.

Mitochondrial dynamics in the regulation of neuronal cell death.

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.

The phosphorylation state of Drp1 determines cell fate.

Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.

Specific in vivo roles for E2Fs in differentiation and development.

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage.

HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression.

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.

E2F4 is required for early eye patterning.

The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.

Mitochondria: joining forces to thwart cell death.

Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

Dining in with BCL-2: new guests at the autophagy table.

Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage.

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

Sertad1 plays an essential role in developmental and pathological neuron death.

Reactive oxygen species: stuck in the middle of neurodegeneration.

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

Rb/E2F regulates expression of neogenin during neuronal migration.

MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.

MCL-1 regulates the balance between autophagy and apoptosis.

Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.

The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.

The retinoblastoma protein is essential for survival of postmitotic neurons.

LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.

Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.

Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.

Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.

Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.

Regulation of ischemic neuronal death by E2F4-p130 protein complexes.

Regulation of the VHL/HIF-1 pathway by DJ-1.

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.