Department of Cellular and Molecular Medicine
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The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.
The Journal of cell biology Jul, 2007 | Pubmed ID: 17591923
Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2007 | Pubmed ID: 17537963
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.
Neuron Jul, 2007 | Pubmed ID: 17610816
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2002 | Pubmed ID: 11823715
The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2002 | Pubmed ID: 11896143
Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12091388
Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.
The EMBO journal Jul, 2002 | Pubmed ID: 12093735
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death.
The Journal of cell biology Aug, 2002 | Pubmed ID: 12147675
Caspase 3 activity is required for skeletal muscle differentiation.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2002 | Pubmed ID: 12177420
Calpains mediate p53 activation and neuronal death evoked by DNA damage.
The Journal of biological chemistry Jul, 2003 | Pubmed ID: 12721303
Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2003 | Pubmed ID: 12764095
Growth factors: can they promote neurogenesis?
Trends in neurosciences Jun, 2003 | Pubmed ID: 12798593
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12857758
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2003 | Pubmed ID: 14595022
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2004 | Pubmed ID: 15044535
Role of AIF in caspase-dependent and caspase-independent cell death.
Oncogene Apr, 2004 | Pubmed ID: 15077142
The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15105421
Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.
Cancer cell Jun, 2004 | Pubmed ID: 15193257
p107 regulates neural precursor cells in the mammalian brain.
The Journal of cell biology Sep, 2004 | Pubmed ID: 15353549
Emerging role for ERK as a key regulator of neuronal apoptosis.
Science's STKE : signal transduction knowledge environment Sep, 2004 | Pubmed ID: 15383672
p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2004 | Pubmed ID: 15525786
c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.
The Journal of biological chemistry Jan, 2005 | Pubmed ID: 15528206
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis.
The Journal of clinical investigation Feb, 2005 | Pubmed ID: 15668733
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2005 | Pubmed ID: 15703386
Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2005 | Pubmed ID: 16166266
Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2005 | Pubmed ID: 16192386
A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration.
The EMBO journal Dec, 2005 | Pubmed ID: 16308563
Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.
Journal of neurochemistry Jan, 2006 | Pubmed ID: 16336220
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2006 | Pubmed ID: 16407541
Novel functions for cell cycle genes in nervous system development.
Cell cycle (Georgetown, Tex.) Jul, 2006 | Pubmed ID: 16861920
Urine concentrating defect in prostaglandin EP1-deficient mice.
American journal of physiology. Renal physiology Feb, 2007 | Pubmed ID: 16885154
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.
The EMBO journal Sep, 2006 | Pubmed ID: 16917506
The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2006 | Pubmed ID: 16928871
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.
Molecular and cellular biology Jul, 2007 | Pubmed ID: 17452454
Mitochondrial dynamics in the regulation of neuronal cell death.
Apoptosis : an international journal on programmed cell death May, 2007 | Pubmed ID: 17453163
Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.
The Journal of biological chemistry Aug, 2007 | Pubmed ID: 17537722
The phosphorylation state of Drp1 determines cell fate.
EMBO reports Oct, 2007 | Pubmed ID: 17906671
Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.
The Journal of biological chemistry Jan, 2008 | Pubmed ID: 17984095
Specific in vivo roles for E2Fs in differentiation and development.
Cell cycle (Georgetown, Tex.) Dec, 2007 | Pubmed ID: 17993781
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2007 | Pubmed ID: 18003894
Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.
Journal of neurochemistry May, 2008 | Pubmed ID: 18205749
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18218782
CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2008 | Pubmed ID: 18495890
HES1 regulates 5-HT1A receptor gene transcription at a functional polymorphism: essential role in developmental expression.
Molecular and cellular neurosciences Jul, 2008 | Pubmed ID: 18499474
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18550749
E2F4 is required for early eye patterning.
Developmental neuroscience , 2009 | Pubmed ID: 19325228
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.
Molecular and cellular biology Sep, 2009 | Pubmed ID: 19564414
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Human molecular genetics Nov, 2009 | Pubmed ID: 19692353
Mitochondria: joining forces to thwart cell death.
Biochimica et biophysica acta Jan, 2010 | Pubmed ID: 19747972
Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19812325
Dining in with BCL-2: new guests at the autophagy table.
Clinical science (London, England : 1979) Feb, 2010 | Pubmed ID: 19845510
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage.
Journal of neurochemistry Jan, 2010 | Pubmed ID: 19895669
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133695
Sertad1 plays an essential role in developmental and pathological neuron death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2010 | Pubmed ID: 20237268
Reactive oxygen species: stuck in the middle of neurodegeneration.
Journal of Alzheimer's disease : JAD , 2010 | Pubmed ID: 20421690
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.
Nature cell biology Jun, 2010 | Pubmed ID: 20473298
The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.
The Journal of biological chemistry Feb, 2011 | Pubmed ID: 21041314
Rb/E2F regulates expression of neogenin during neuronal migration.
Molecular and cellular biology Jan, 2011 | Pubmed ID: 21059867
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
The EMBO journal Jan, 2011 | Pubmed ID: 21139567
MCL-1 regulates the balance between autophagy and apoptosis.
Autophagy May, 2011 | Pubmed ID: 21412051
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
The Journal of biological chemistry Jun, 2012 | Pubmed ID: 22511790
The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2012 | Pubmed ID: 22699903
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.
Human molecular genetics Nov, 2012 | Pubmed ID: 22872702
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy Apr, 2012 | Pubmed ID: 22966490
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2012 | Pubmed ID: 23019375
The retinoblastoma protein is essential for survival of postmitotic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2012 | Pubmed ID: 23077065
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.
Human molecular genetics Mar, 2013 | Pubmed ID: 23187960
Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.
Cell stem cell Apr, 2013 | Pubmed ID: 23499385
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2013 | Pubmed ID: 23536090
Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
The Journal of biological chemistry May, 2013 | Pubmed ID: 23536182
LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.
Cell cycle (Georgetown, Tex.) May, 2013 | Pubmed ID: 23574720
Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.
Molecular and cellular biology Jul, 2013 | Pubmed ID: 23689134
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.
Nature communications , 2014 | Pubmed ID: 24686499
Regulation of ischemic neuronal death by E2F4-p130 protein complexes.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24828495
Regulation of the VHL/HIF-1 pathway by DJ-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2014 | Pubmed ID: 24899725
DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.
PloS one , 2014 | Pubmed ID: 25210784
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
The EMBO journal Nov, 2014 | Pubmed ID: 25298396