David G. Harrison

The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis.

The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation.

Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase.

Free radicals in heart failure: therapeutic targets for old and new drugs.

Extracellular superoxide dismutase and cardiovascular disease.

Maintenance of a functional endothelial cell monolayer on a fibroblast/polymer substrate under physiologically relevant shear stress conditions.

Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity.

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II.

Detection of superoxide in vascular tissue.

Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke.

Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase.

Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide.

Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training.

Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation.

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension.

Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.

Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress.

Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.

The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases.

Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding.

Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase.

Endothelial control of vasomotion and nitric oxide production.

Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma.

C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.

Established and emerging plasma biomarkers in the prediction of first atherothrombotic events.

Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII.

Oxidative stress and diabetic vascular complications.

Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay.

Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle.

Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice.

ATVB in focus: redox mechanisms in blood vessels.

Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease.

Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase.

Role of antioxidant-1 in extracellular superoxide dismutase function and expression.

The shear stress of keeping arteries clear.

Laminar shear stress and 3' polyadenylation of eNOS mRNA.

Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium.

Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase.

A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription.

The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress.

Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases.

Can vitamin E prevent cardiovascular events and cancer?

Coronary artery superoxide production and nox isoform expression in human coronary artery disease.

RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response.

The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults.

Vascular NADPH oxidases as drug targets for novel antioxidant strategies.

Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation.

Role of extracellular superoxide dismutase in hypertension.

Early determinants of H2O2-induced endothelial dysfunction.

Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.

Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes.

Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II.

Measurement of reactive oxygen species in cardiovascular studies.

Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease?

Regulation of tetrahydrobiopterin biosynthesis by shear stress.

Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction.

Sad heart from no SOD.

Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction.

Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity.

Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription.

Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults.

Enhanced hype.

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production.

Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function.

Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.

Is hypertension an immunologic disease?

Doubt about an essential role for constitutive nitric oxide synthase in nitroglycerin-mediated vasodilation.

Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease.

Regulation of T-cell function by endogenously produced angiotensin II.

Molecular beacons can assess changes in expression and 3'-polyadenylation of human eNOS mRNA.

Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes.

Blood pressure control: salt gets under your skin.

Oxidative stress and hypertension.

Targeted detoxification of selected reactive oxygen species in the vascular endothelium.

GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.

Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system.

Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction.

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction.

NO solution for a radical problem: a TAL story.

Role of the adaptive immune system in hypertension.

Oxidative stress and hypertension.

Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study.

Therapeutic targeting of mitochondrial superoxide in hypertension.

Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury.

Central and peripheral mechanisms of T-lymphocyte activation and vascular inflammation produced by angiotensin II-induced hypertension.

Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling.

Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications.

Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension.

Inflammation, immunity, and hypertension.

The central nervous system and inflammation in hypertension.

Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation.

Localization of culprit lesions in coronary arteries of patients with ST-segment elevation myocardial infarctions: relation to bifurcations and curvatures.

Just not himself these days: an invitation to submit papers on the topic of inflammation and immunity in organ systems physiology and pathophysiology.

Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice.

Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.

A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin.

Role of vascular extracellular superoxide dismutase in hypertension.

Requirement of argininosuccinate lyase for systemic nitric oxide production.

What fans the fire: insights into mechanisms of inflammation in atherosclerosis and diabetes mellitus.