Hanjoong Jo

Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase A.

Activation of c-Jun N-terminal kinase and apoptosis in endothelial cells mediated by endogenous generation of hydrogen peroxide.

Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.

NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II.

Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism.

Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase.

IkappaBalpha-dependent regulation of low-shear flow-induced NF-kappa B activity: role of nitric oxide.

Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells.

Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response.

Optimization of isolation and functional characterization of primary murine aortic endothelial cells.

A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscle.

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases.

Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress.

Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.

Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase.

High glucose induced NF-kappaB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress: role of nitric oxide.

Bovine caveolin-2 cloning and effects of shear stress on its localization in bovine aortic endothelial cells.

Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.

Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts.

Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress.

Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase.

Plasma membrane requirements for 1alpha,25(OH)2D3 dependent PKC signaling in chondrocytes and osteoblasts.

Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase mu.

Laminar shear stress inhibits cathepsin L activity in endothelial cells.

Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells.

Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation.

Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization.

Embryonic stem cell-derived endothelial cells may lack complete functional maturation in vitro.

Early determinants of H2O2-induced endothelial dysfunction.

Role of NADPH oxidases in disturbed flow- and BMP4- induced inflammation and atherosclerosis.

Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1.

An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch.

Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves.

An improved method to measure nitrate/nitrite with an NO-selective electrochemical sensor.

Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis.

Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes.

Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine.

Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway.

Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death.

Caveolin-1 knockout mice have increased bone size and stiffness.

Emerging role of IGF-1R in stretch-induced neointimal hyperplasia in venous grafts.

NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives.

Laminar shear inhibits tubule formation and migration of endothelial cells by an angiopoietin-2 dependent mechanism.

Bone morphogenic protein antagonists are coexpressed with bone morphogenic protein 4 in endothelial cells exposed to unstable flow in vitro in mouse aortas and in human coronary arteries: role of bone morphogenic protein antagonists in inflammation and atherosclerosis.

Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidant.

Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons.

X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival.

Design of an ex vivo culture system to investigate the effects of shear stress on cardiovascular tissue.

Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells.

Angiopoietin-2 stimulates blood flow recovery after femoral artery occlusion by inducing inflammation and arteriogenesis.

Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells.

Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway.

Low magnitude and high frequency mechanical loading prevents decreased bone formation responses of 2T3 preosteoblasts.

Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress.

Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease.

Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome.

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis.

Systems analysis of the role of bone morphogenic protein 4 in endothelial inflammation.

GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide.

Intimal cushions and endothelial nuclear elongation around mouse aortic branches and their spatial correspondence with patterns of lipid deposition.

HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells.

Shear stress and plaque development.

X-linked inhibitor of apoptosis protein controls alpha5-integrin-mediated cell adhesion and migration.

Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner.

Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow.

Animal, in vitro, and ex vivo models of flow-dependent atherosclerosis: role of oxidative stress.

Endothelial metallothionein expression and intracellular free zinc levels are regulated by shear stress.

Detection of low levels of nitric oxide using an electrochemical sensor.

Differences in valvular and vascular cell responses to strain in osteogenic media.

Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome.

The effects of combined cyclic stretch and pressure on the aortic valve interstitial cell phenotype.

MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells.

Redox going with vascular shear stress.

Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow.

Disturbed flow: p53 SUMOylation in the turnover of endothelial cells.

Preferential activation of SMAD1/5/8 on the fibrosa endothelium in calcified human aortic valves--association with low BMP antagonists and SMAD6.

Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells.

Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice.

Serum BMP-4 levels in relation to arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes.

Dynamic Immune Cell Accumulation During Flow-Induced Atherogenesis in Mouse Carotid Artery: An Expanded Flow Cytometry Method.

Maturing EPCs into endothelial cells: may the force be with the EPCs: focus on "Fluid shear stress induces differentiation of circulating phenotype endothelial progenitor cells".

Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling.

Aortic valve: mechanical environment and mechanobiology.

The role of the vascular dendritic cell network in atherosclerosis.

Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells.

Vascular injury involves the overoxidation of peroxiredoxin type II and is recovered by the peroxiredoxin activity mimetic that induces reendothelialization.

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis.

Development of immortalized mouse aortic endothelial cell lines.

Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.

Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis.

Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs.

Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei.

Fluid Mechanics, Arterial Disease, and Gene Expression.

The Role of Mechanical Stimulation in Recovery of Bone Loss-High versus Low Magnitude and Frequency of Force.

Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis.

Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo.

The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.

Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.

Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries.

Vascular Proteomics Reveal Novel Proteins Involved in SMC Phenotypic Change: OLR1 as a SMC Receptor Regulating Proliferation and Inflammatory Response.

Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE(-/-) Mice.

The NADPH oxidase Nox4 has anti-atherosclerotic functions.

The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches.

Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis.

Discovery of novel peptides targeting pro-atherogenic endothelium in disturbed flow regions -Targeted siRNA delivery to pro-atherogenic endothelium in vivo.

Deep transcriptomic profiling reveals the similarity between endothelial cells cultured under static and oscillatory shear stress conditions.

Simulated Microgravity and 3D Culture Enhance Induction, Viability, Proliferation and Differentiation of Cardiac Progenitors from Human Pluripotent Stem Cells.

Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene.

Mechanosensitive microRNA-181b Regulates Aortic Valve Endothelial Matrix Degradation by Targeting TIMP3.

KLF2 and KLF4 control endothelial identity and vascular integrity.

Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation.

Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.

Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.

Conserved Gene Microsynteny Unveils Functional Interaction Between Protein Disulfide Isomerase and Rho Guanine-Dissociation Inhibitor Families.

Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin.

3D Imaging and Quantitative Analysis of Vascular Networks: A Comparison of Ultramicroscopy and Micro-Computed Tomography.

ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

Role of flow-sensitive microRNAs and long noncoding RNAs in vascular dysfunction and atherosclerosis.

Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells.

miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification.

Conditional Deoxyribozyme-Nanoparticle Conjugates for miRNA-Triggered Gene Regulation.

Deletion of NoxO1 limits atherosclerosis development in female mice.

Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis.

Delivery of Anti-microRNA-712 to Inflamed Endothelial Cells Using Poly(β-amino ester) Nanoparticles Conjugated with VCAM-1 Targeting Peptide.

Very late vasomotor responses and gene expression with bioresorbable scaffolds and metallic drug-eluting stents.

Combined LXR and RXR Agonist Therapy Increases ABCA1 Protein Expression and Enhances ApoAI-Mediated Cholesterol Efflux in Cultured Endothelial Cells.