Vivien R. Sutton

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis.

Granzyme B: pro-apoptotic, antiviral and antitumor functions.

A central role for Bid in granzyme B-induced apoptosis.

A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function.

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.

Cathepsin H is an additional convertase of pro-granzyme B.

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L.

Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.

Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.

A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

Activated mouse B cells lack expression of granzyme B.

A novel role for granzymes in anti-tumor immunity.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Granzyme h is a novel protease expressed by human mast cells.