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Cancer Immunology Program
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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.
The Journal of cell biology Jan, 2003 | Pubmed ID: 12538642
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.
Immunity Mar, 2003 | Pubmed ID: 12648450
Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis.
Journal of immunological methods May, 2003 | Pubmed ID: 12738359
Granzyme B: pro-apoptotic, antiviral and antitumor functions.
Current opinion in immunology Oct, 2003 | Pubmed ID: 14499262
A central role for Bid in granzyme B-induced apoptosis.
The Journal of biological chemistry Feb, 2005 | Pubmed ID: 15574417
A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.
Transplantation Jan, 2006 | Pubmed ID: 16436955
Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.
The Journal of cell biology Apr, 2006 | Pubmed ID: 16606695
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.
Diabetes Aug, 2006 | Pubmed ID: 16873683
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
The Journal of cell biology Feb, 2007 | Pubmed ID: 17283185
Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function.
Blood Aug, 2007 | Pubmed ID: 17475905
Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.
Methods (San Diego, Calif.) Mar, 2008 | Pubmed ID: 18314055
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.
Journal of medicinal chemistry Dec, 2008 | Pubmed ID: 19007200
Cathepsin H is an additional convertase of pro-granzyme B.
The Journal of biological chemistry Jul, 2010 | Pubmed ID: 20435891
Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L.
Immunology Oct, 2010 | Pubmed ID: 20497254
Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.
Biological chemistry Aug, 2010 | Pubmed ID: 20731542
Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.
Immunology and cell biology May, 2011 | Pubmed ID: 20975734
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21709155
Activated mouse B cells lack expression of granzyme B.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2012 | Pubmed ID: 22427643
A novel role for granzymes in anti-tumor immunity.
Oncoimmunology Mar, 2012 | Pubmed ID: 22720248
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.
Blood Apr, 2013 | Pubmed ID: 23377437
Granzyme h is a novel protease expressed by human mast cells.
International archives of allergy and immunology , 2014 | Pubmed ID: 25342632
Peter MacCallum Cancer Centre
Magdalena Hagn1,
Vivien R. Sutton1,
Joseph A. Trapani1
1Cancer Immunology Program, Peter MacCallum Cancer Centre
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