Paul D. W. Eckford

Reconstitution of membrane transporters.

The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids.

New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter.

P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors.

Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.

Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport.

ABC efflux pump-based resistance to chemotherapy drugs.

The reconstituted Escherichia coli MsbA protein displays lipid flippase activity.

Targeting the regulation of CFTR channels.

Structural basis for alginate secretion across the bacterial outer membrane.

Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy.

Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator.

Identification and validation of hits from high throughput screens for CFTR modulators.

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.

Functional Rescue of F508del-CFTR Using Small Molecule Correctors.

Proton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membrane.

VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.