Programme in Molecular Structure and Function
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Reconstitution of membrane transporters.
Methods in molecular biology (Clifton, N.J.) , 2003 | Pubmed ID: 12824648
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids.
The Biochemical journal Jul, 2005 | Pubmed ID: 15799713
New insights into the drug binding, transport and lipid flippase activities of the p-glycoprotein multidrug transporter.
Journal of bioenergetics and biomembranes Dec, 2005 | Pubmed ID: 16691487
P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors.
Biochemistry and cell biology = Biochimie et biologie cellulaire Dec, 2006 | Pubmed ID: 17215888
Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.
The Journal of biological chemistry May, 2008 | Pubmed ID: 18344567
Interaction of the P-glycoprotein multidrug efflux pump with cholesterol: effects on ATPase activity, drug binding and transport.
Biochemistry Dec, 2008 | Pubmed ID: 19049391
ABC efflux pump-based resistance to chemotherapy drugs.
Chemical reviews Jul, 2009 | Pubmed ID: 19583429
The reconstituted Escherichia coli MsbA protein displays lipid flippase activity.
The Biochemical journal Jul, 2010 | Pubmed ID: 20412049
Targeting the regulation of CFTR channels.
The Biochemical journal Apr, 2011 | Pubmed ID: 21726198
Structural basis for alginate secretion across the bacterial outer membrane.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2011 | Pubmed ID: 21778407
Insights into the mechanisms underlying CFTR channel activity, the molecular basis for cystic fibrosis and strategies for therapy.
Essays in biochemistry Sep, 2011 | Pubmed ID: 21967060
Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator.
Journal of medicinal chemistry Dec, 2011 | Pubmed ID: 22074181
Identification and validation of hits from high throughput screens for CFTR modulators.
Current pharmaceutical design , 2012 | Pubmed ID: 22229556
Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22942289
Functional Rescue of F508del-CFTR Using Small Molecule Correctors.
Frontiers in pharmacology , 2012 | Pubmed ID: 23055971
Proton-dependent gating and proton uptake by Wzx support O-antigen-subunit antiport across the bacterial inner membrane.
mBio , 2013 | Pubmed ID: 24023388
VX-809 and related corrector compounds exhibit secondary activity stabilizing active F508del-CFTR after its partial rescue to the cell surface.
Chemistry & biology May, 2014 | Pubmed ID: 24726831
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