Willard M. Freeman

Changes in rat frontal cortex gene expression following chronic cocaine.

Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression.

Systematic screening of gene expression using a cDNA macroarray.

Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity.

Use of microarray technologies in toxicology research.

An interactive database of cocaine-responsive gene expression.

Functional genomic analysis in pain research using hybridization arrays.

Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats.

Proteomics for protein expression profiling in neuroscience.

Manganese-induced cytotoxicity in dopamine-producing cells.

Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats.

Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration.

Depletion of abundant proteins from non-human primate serum for biomarker studies.

Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.

Plasma proteomics: a noninvasive window on pathology and pediatric cardiac surgery.

Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration.

Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass.

Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior.

Twenty-five years of quantitative PCR for gene expression analysis.

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.

Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina.

Human embryonic and mesenchymal stem cells express different nuclear proteomes.

Age-related changes in the expression and oxidation of bronchoalveolar lavage proteins in the rat.

Correlating human and animal studies of cocaine abuse and gene expression.

Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin.

The impact of surfactant protein-A on ozone-induced changes in the mouse bronchoalveolar lavage proteome.

Pediatric cardiopulmonary bypass circuits: a review of studies conducted at the Penn State Pediatric Cardiac Research Laboratories.

FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK).

Gene expression changes following extinction testing in a heroin behavioral incubation model.

The use of neuroproteomics in drug abuse research.

Circulating cytokines as biomarkers of alcohol abuse and alcoholism.

Transcriptomic comparison of the retina in two mouse models of diabetes.

Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration.

Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration.

Classification of alcohol abuse by plasma protein biomarkers.

Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass.

Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders.

Aging alters the expression of neurotransmission-regulating proteins in the hippocampal synaptoproteome.

Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury.

Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice.

Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization.

Individual differences in hyperlipidemia and vitamin E status in response to chronic alcohol self-administration in cynomolgus monkeys.

2-D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells.

Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy.

TPH2 in the ventral tegmental area of the male rat brain.

Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration.

Hippocampal dysregulation of synaptic plasticity-associated proteins with age-related cognitive decline.

Chronic insulin treatment of diabetes does not fully normalize alterations in the retinal transcriptome.

Age-related alterations in retinal neurovascular and inflammatory transcripts.

The hippocampal neuroproteome with aging and cognitive decline: past progress and future directions.

Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment.

A Longitudinal Analysis of Circulating Stress-Related Proteins and Chronic Ethanol Self-Administration in Cynomolgus Macaques.

The kinetics of cardiopulmonary bypass: a dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass.

Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory.

Nanoliposomal minocycline for ocular drug delivery.

Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.

Quantification of Hepatic UDP glucuronosyltransferase 1A splice variant expression and correlation of UDP glucuronosyltransferase 1A1 variant expression with glucuronidation activity.

Protein biomarkers of alcohol abuse.

Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition.

Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.

Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing.

Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways.

Insulin treatment normalizes retinal neuroinflammation but not markers of synapse loss in diabetic rats.

Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline.

Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data.

CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging.

Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation.

Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle.

Role of DNA methylation in the dietary restriction mediated cellular memory.

Functional changes in the neural retina occur in the absence of mitochondrial dysfunction in a rodent model of diabetic retinopathy.

Sexually divergent DNA methylation patterns with hippocampal aging.

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.

Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline.

The role of DNA methylation in epigenetics of aging.

Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.

Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues.

Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia.

Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer.

Exercising your mind.

Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.

Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer.

Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia.

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α.

Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion.

Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells.

Long-term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice.

Litter expansion alters metabolic homeostasis in a sex specific manner.

Oklahoma Nathan Shock Aging Center - assessing the basic biology of aging from genetics to protein and function.

Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging.

Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain.

The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.

Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia.

Minimizing the Confounds of Cell-Isolation Techniques on Transcriptomic and Translatomic Profiles of Purified Microglia.

Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex.

An RNA-seq study of the mPFC of rats with different addiction phenotypes.

Translatomic response of retinal Müller glia to acute and chronic stress.

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice.

Isolation of Neuronal Synaptic Membranes by Sucrose Gradient Centrifugation.

Chromosomal and gonadal factors regulate microglial sex effects in the aging brain.