Irma Joosten

Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects.

Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies.

Superior T-cell suppression by rapamycin and FK506 over rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory responses, and persistent apoptosis.

The proportion of follicular fluid CD16+CD56DIM NK cells is increased in IVF patients with idiopathic infertility.

IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression.

Shift in expression of HLA-G mRNA spliceforms in pregnancies complicated by preeclampsia.

A novel bispecific antihuman CD40/CD86 fusion protein with t-cell tolerizing potential.

Tolerizing effects of co-stimulation blockade rest on functional dominance of CD4+CD25+ regulatory T cells.

CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells.

Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitro.

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells.

Activation of NK cells by an endocytosed receptor for soluble HLA-G.

KIR and Human Leukocyte Antigen Genotype Associated Risk of Cytomegalovirus Disease in Renal Transplant Patients.

CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade.

Ex vivo expansion of human CD4+ CD25high regulatory T cells from transplant recipients permits functional analysis of small blood samples.

The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells.

Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity.

Allogeneic stimulation of naturally occurring CD4+CD25+ T cells induces strong regulatory capacity with increased donor-reactivity.

KIR gene and KIR ligand analysis to predict graft rejection after renal transplantation.

The presence of donor-specific human leukocyte antigen antibodies does not preclude successful withdrawal of tacrolimus in stable renal transplant recipients.

A novel (Leu183Pro-)mutation in the HFE-gene co-inherited with the Cys282Tyr mutation in two unrelated Dutch hemochromatosis patients.

Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy.

KIR2DS5 is associated with leukemia free survival after HLA identical stem cell transplantation in chronic myeloid leukemia patients.

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells.

Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus.

Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation.

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.

Limited amounts of dendritic cells migrate into the T-cell area of lymph nodes but have high immune activating potential in melanoma patients.

The macrophage mannose receptor induces IL-17 in response to Candida albicans.

The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.

High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy.

DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells.

Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation.

Immunotherapy with regulatory T cells in transplantation.

1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses.

Anaphylaxis from passive transfer of peanut allergen in a blood product.

Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production.

Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin.

Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome.

1,25-Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells.

Koebner phenomenon in psoriasis is not associated with deletion of late cornified envelope genes LCE3B and LCE3C.

Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.

Analyzing the homeostasis of signaling proteins by a combination of Western blot and fluorescence correlation spectroscopy.

Translating the role of vitamin D3 in infectious diseases.

Defining early human NK cell developmental stages in primary and secondary lymphoid tissues.

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling.

Rho kinase inhibitor Y-27632 prolongs the life span of adult human keratinocytes, enhances skin equivalent development, and facilitates lentiviral transduction.

Humoral anti-KLH responses in cancer patients treated with dendritic cell-based immunotherapy are dictated by different vaccination parameters.

High-dose vitamin D3 supplementation is a requisite for modulation of skin-homing markers on regulatory T cells in HIV-infected patients.

Storage-induced changes in erythrocyte membrane proteins promote recognition by autoantibodies.

Humanized mouse model of skin inflammation is characterized by disturbed keratinocyte differentiation and influx of IL-17A producing T cells.

Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations.

CD19 is a useful B cell marker after treatment with rituximab: comment on the article by Jones et al.

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.

Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya.

The effects of in vivo B-cell depleting therapy on ex-vivo cytokine production.

Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells.

Gateway to understanding microparticles: standardized isolation and identification of plasma membrane-derived vesicles.

Phosphatidylserine exposure on stored red blood cells as a parameter for donor-dependent variation in product quality.

Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases.

Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production.

Selective expansion of human natural killer cells leads to enhanced alloreactivity.

Immune responses to stress after stress management training in patients with rheumatoid arthritis.

In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17.

The impact of exercise on the variation of serum free light chains.

Immune responses to stress in rheumatoid arthritis and psoriasis.

Cellular sources of IL-17 in psoriasis: a paradigm shift?

Redefining Strategies to Introduce Tolerance-Inducing Cellular Therapy in Human beings to Combat Autoimmunity and Transplantation Reactions.

The interplay between antiviral immunity and allo-immune reactivity after renal transplantation: consortium between the Centres Amsterdam, Leiden and Nijmegen (ALLOVIR).

Balance of Treg versus T-effector cells during systemic treatment with adalimumab and topical treatment with calcipotriol-betamethasone dipropionate ointment.

Longitudinal analysis of T and B cell phenotype and function in renal transplant recipients with or without rituximab induction therapy.

Soluble CD30 does not predict late acute rejection or safe tapering of immunosuppression in renal transplantation.

The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study.

Cytokine Release After Treatment With Rituximab in Renal Transplant Recipients.

Prominent HLA-G Expression in Liver Disease But Not After Liver Transplantation.

Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.

Quantitative measurement of immunoglobulins and free light chains using mass spectrometry.

The role of interleukin-1 beta in the pathophysiology of Schnitzler's syndrome.

Platelet-derived microparticles inhibit IL-17 production by regulatory T cells through P-selectin.