Christopher M. Waters

Continuous exposure of airway epithelial cells to hydrogen peroxide: protection by KGF.

Cellular biomechanics in the lung.

Mechanism of glutamate stimulation of CO production in cerebral microvessels.

Enterococcus faecalis plasmid pAD1-encoded Fst toxin affects membrane permeability and alters cellular responses to lantibiotics.

Role of the Enterococcus faecalis GelE protease in determination of cellular chain length, supernatant pheromone levels, and degradation of fibrin and misfolded surface proteins.

The aggregation domain of aggregation substance, not the RGD motifs, is critical for efficient internalization by HT-29 enterocytes.

Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element.

Mathematical modeling of airway epithelial wound closure during cyclic mechanical strain.

Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2 levels: essential role of cGMP.

Actin re-distribution in response to hydrogen peroxide in airway epithelial cells.

An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid.

Ionic mechanisms mediating the myogenic response in newborn porcine cerebral arteries.

Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF.

RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells.

Reactive oxygen species in mechanotransduction.

Regulation of cell motility by tyrosine phosphorylated villin.

Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells.

KGF prevents oxygen-mediated damage in ARPE-19 cells.

Quorum sensing: cell-to-cell communication in bacteria.

Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.

Pharmacokinetic considerations in the treatment of CNS tumours.

The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers.

Topotecan central nervous system penetration is altered by a tyrosine kinase inhibitor.

Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin.

High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion.

Airway strain during mechanical ventilation in an intact animal model.

A negative feedback loop involving small RNAs accelerates Vibrio cholerae's transition out of quorum-sensing mode.

Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT.

IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release.

Localized elasticity measured in epithelial cells migrating at a wound edge using atomic force microscopy.

Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier.

Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.

A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi.

Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid.

Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells.

Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.

Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation.

Epithelial repair mechanisms in the lung.

Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas.

Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA.

P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice.

Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes.

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis.

Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner.

Balance of life and death in alveolar epithelial type II cells: proliferation, apoptosis, and the effects of cyclic stretch on wound healing.

Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation.

What do we know about mechanical strain in lung alveoli?

Integration of cyclic di-GMP and quorum sensing in the control of vpsT and aphA in Vibrio cholerae.

Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells.

Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice.

Molecular mechanism of interleukin-2-induced mucosal homeostasis.

CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-2.

Hyperoxia alters the mechanical properties of alveolar epithelial cells.

Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile.

A tangled web: regulatory connections between quorum sensing and cyclic Di-GMP.

Evolution of resistance to quorum quenching in digital organisms.

Quantification of high-specificity cyclic diguanylate signaling.

Correlation between in vivo biofilm formation and virulence gene expression in Escherichia coli O104:H4.

Identification of small molecules that antagonize diguanylate cyclase enzymes to inhibit biofilm formation.

Hfq-dependent, co-ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis.

Bacterial wheel locks: extracellular polysaccharide inhibits flagellar rotation.

Exposure of Salmonella enterica Serovar Typhimurium to a Protective Monoclonal IgA Triggers Exopolysaccharide Production via a Diguanylate Cyclase-Dependent Pathway.

Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells.

Cyclic Di-GMP Modulates the Disease Progression of Erwinia amylovora.

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

Insulin-like growth factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a.

Mechanobiology in lung epithelial cells: measurements, perturbations, and responses.

Exploring environmental control of cyclic di-GMP signaling in Vibrio cholerae by using the ex vivo lysate cyclic di-GMP assay (TELCA).

Genetic analysis of Agrobacterium tumefaciens unipolar polysaccharide production reveals complex integrated control of the motile-to-sessile switch.

Post-transcriptional activation of a diguanylate cyclase by quorum sensing small RNAs promotes biofilm formation in Vibrio cholerae.

Occurrence of cyclic di-GMP-modulating output domains in cyanobacteria: an illuminating perspective.

Regulation of Monocyte Chemotactic Protein-1 secretion by the Two-Pore-Domain Potassium (K2P) channel TREK-1 in human alveolar epithelial cells.

Two DHH subfamily 1 proteins in Streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence.

Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development.

Cyclic di-GMP inhibits Vibrio cholerae motility by repressing induction of transcription and inducing extracellular polysaccharide production.

Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase.

The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP.

The 2-pore domain potassium channel TREK-1 regulates stretch-induced detachment of alveolar epithelial cells.

Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism.

Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae.

Modulation of radiation injury response in retinal endothelial cells by quinic acid derivative KZ-41 involves p38 MAPK.

Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury.

Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis.

Deciphering the components that coordinately regulate virulence factors of the soft rot pathogen Dickeya dadantii.

Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus.

The Meteoric Rise of the Signaling Molecule Cyclic di-GMP.

The Yersinia pestis HmsCDE regulatory system is essential for blockage of the oriental rat flea (Xenopsylla cheopis), a classic plague vector.

Intestinal GPS: bile and bicarbonate control cyclic di-GMP to provide Vibrio cholerae spatial cues within the small intestine.

The Cyclic Di-GMP Phosphodiesterase Gene Rv1357c/BCG1419c Affects BCG Pellicle Production and In Vivo Maintenance.

Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase.

TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements.

A Pterin-Dependent Signaling Pathway Regulates a Dual-Function Diguanylate Cyclase-Phosphodiesterase Controlling Surface Attachment in Agrobacterium tumefaciens.

Regulation of biofilm formation and cellular buoyancy through modulating intracellular cyclic di-GMP levels in engineered cyanobacteria.

Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.

Cross-talk between a regulatory small RNA, cyclic-di-GMP signalling and flagellar regulator FlhDC for virulence and bacterial behaviours.

Kymographic Imaging of the Elastic Modulus of Epithelial Cells during the Onset of Migration.

Chronic hypersensitivity pneumonitis caused by Saccharopolyspora rectivirgula is not associated with a switch to a Th2 response.

In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens.

Evolution of Ecological Diversity in Biofilms of Pseudomonas aeruginosa by Altered Cyclic Diguanylate Signaling.

Spermidine Inversely Influences Surface Interactions and Planktonic Growth in Agrobacterium tumefaciens.

Bacterial Quorum Sensing Stabilizes Cooperation by Optimizing Growth Strategies.

A Filter Binding Assay to Quantify the Association of Cyclic di-GMP to Proteins.

Polysorbates prevent biofilm formation and pathogenesis of Escherichia coli O104:H4.

Contextual organismality: Beyond pattern to process in the emergence of organisms.

Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response.

Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection.

Calcium-mediated oxidative stress: a common mechanism in tight junction disruption by different types of cellular stress.

A heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing.

Enhancing multiplex genome editing by natural transformation (MuGENT) via inactivation of ssDNA exonucleases.

Cyclic Di-GMP and VpsR Induce the Expression of Type II Secretion in Vibrio cholerae.

Airway Epithelial Repair by a Prebiotic Mannan Derived from Saccharomyces cerevisiae.

Spermine inhibits Vibrio cholerae biofilm formation through the NspS-MbaA polyamine signaling system.

Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.

Spectrophotometric and Mass Spectroscopic Methods for the Quantification and Kinetic Evaluation of In Vitro c-di-GMP Synthesis.