Manuela M. Santos

Frataxin knockin mouse.

Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.

Iron metabolism in mice with partial frataxin deficiency.

Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.

Genomic structure, promoter activity, and developmental expression of the mouse homologue of the Machado-Joseph disease (MJD) gene.

Frataxin overexpressing mice.

Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading.

Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration.

Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation.

Exclusion of mutations in the PRNP, JPH3, TBP, ATN1, CREBBP, POU3F2 and FTL genes as a cause of disease in Portuguese patients with a Huntington-like phenotype.

Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha.

Anemia upregulates lipocalin 2 in the liver and serum.

Is the iron donor lipocalin 2 implicated in the pathophysiology of hereditary hemochromatosis?

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli.

Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.

Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter.

Toll-like receptor signal adaptor protein MyD88 is required for sustained endotoxin-induced acute hypoferremic response in mice.

Bacterial cell wall constituents induce hepcidin expression in macrophages through MyD88 signaling.

Extraction of high added value biological compounds from sardine, sardine-type fish and mackerel canning residues--a review.

The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation.

Hfe and Hjv exhibit overlapping functions for iron signaling to hepcidin.

T lymphocyte-derived TNF and IFN-γ repress HFE expression in cancer cells.

Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis.

Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains.

Improvement of colonic healing and surgical recovery with perioperative supplementation of inulin and galacto-oligosaccharides.

Oral iron supplementation after antibiotic exposure induces a deleterious recovery of the gut microbiota.