Harry Heimberg

Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.

Purification of rat pancreatic B-cells by fluorescence-activated cell sorting.

Nestin is expressed in vascular endothelial cells in the adult human pancreas.

Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.

EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.

Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas.

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.

Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development.

The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells.

Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.

Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).

Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.

Beta cells within single human islets originate from multiple progenitors.

Boosting beta-cell numbers.

Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.

The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.

Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.

Ectopic expression of E2F1 stimulates beta-cell proliferation and function.

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program.

Pancreatic beta-cells: from generation to regeneration.

Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.

Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.

Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.

Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.

Gene delivery to pancreatic exocrine cells in vivo and in vitro.

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration.

Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing β-Like Cells.

Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells.

Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function.

Mouse beta cell proliferation is inhibited by thymidine analogue labelling.

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.

Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.

The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.

Reversal of hyperglycemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes.

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.

Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.

Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells.

IL-6-dependent proliferation of alpha cells in mice with partial pancreatic-duct ligation.

Partial duct ligation: β-cell proliferation and beyond.

Clinical Immunosuppressants Inhibit Inflammatory, Proliferative And Reprogramming Potential, But Not Angiogenesis Of Human Pancreatic Duct Cells.

In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.

Combining MK626, a novel DPP-4 inhibitor, and low-dose monoclonal CD3 antibody for stable remission of new-onset diabetes in mice.

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.

Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration.

Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor.

Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury.

Islet Transplantation for Type 1 Diabetes: So Close and Yet So Far away.