Diabetes Research Center
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Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.
Endocrinology Jan, 2002 | Pubmed ID: 11751624
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.
The Journal of cell biology Oct, 2002 | Pubmed ID: 12403815
Purification of rat pancreatic B-cells by fluorescence-activated cell sorting.
Methods in molecular medicine , 2003 | Pubmed ID: 12619712
Nestin is expressed in vascular endothelial cells in the adult human pancreas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Jun, 2003 | Pubmed ID: 12754281
Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling.
Diabetes Oct, 2003 | Pubmed ID: 14514632
Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.
Biochemical and biophysical research communications Dec, 2003 | Pubmed ID: 14651961
Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.
Gene expression , 2003 | Pubmed ID: 14686787
Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.
Biochemical pharmacology Aug, 2004 | Pubmed ID: 15242807
EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.
Laboratory investigation; a journal of technical methods and pathology Jan, 2005 | Pubmed ID: 15543206
Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.
Life sciences Jul, 2005 | Pubmed ID: 15893773
IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
The EMBO journal Mar, 2006 | Pubmed ID: 16511571
Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas.
The American journal of pathology Oct, 2006 | Pubmed ID: 17003479
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.
Free radical biology & medicine Jan, 2007 | Pubmed ID: 17157194
Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development.
Stem cells (Dayton, Ohio) May, 2007 | Pubmed ID: 17272496
The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy. Workshop on programming pancreatic beta-cells.
EMBO reports Apr, 2007 | Pubmed ID: 17363969
Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.
Cell Jan, 2008 | Pubmed ID: 18243096
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.
Biochemical pharmacology May, 2008 | Pubmed ID: 18377870
Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).
The journal of gene medicine Jul, 2008 | Pubmed ID: 18470950
Investigation and characterization of the duct cell-enriching process during serum-free suspension and monolayer culture using the human exocrine pancreas fraction.
Pancreas Jan, 2009 | Pubmed ID: 18665014
Beta cells within single human islets originate from multiple progenitors.
PloS one , 2008 | Pubmed ID: 18958289
Boosting beta-cell numbers.
The New England journal of medicine Dec, 2008 | Pubmed ID: 19092158
Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.
Gastroenterology May, 2009 | Pubmed ID: 19208356
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells.
Cell Aug, 2009 | Pubmed ID: 19665969
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.
Developmental cell Dec, 2009 | Pubmed ID: 20059954
Ectopic expression of E2F1 stimulates beta-cell proliferation and function.
Diabetes Jun, 2010 | Pubmed ID: 20299467
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program.
Genome research Jun, 2010 | Pubmed ID: 20395405
Pancreatic beta-cells: from generation to regeneration.
Seminars in cell & developmental biology Oct, 2010 | Pubmed ID: 20688184
Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.
Cell transplantation , 2011 | Pubmed ID: 21294959
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.
Gastroenterology Aug, 2011 | Pubmed ID: 21703267
Clusters of conserved beta cell marker genes for assessment of beta cell phenotype.
PloS one , 2011 | Pubmed ID: 21912665
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.
Gut Dec, 2012 | Pubmed ID: 22271799
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.
PloS one , 2012 | Pubmed ID: 22606327
Gene delivery to pancreatic exocrine cells in vivo and in vitro.
BMC biotechnology , 2012 | Pubmed ID: 23088534
Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration.
Development (Cambridge, England) Feb, 2013 | Pubmed ID: 23325761
Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing β-Like Cells.
Diabetes Apr, 2013 | Pubmed ID: 23610058
Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells.
PloS one , 2013 | Pubmed ID: 23671681
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Developmental cell Jul, 2013 | Pubmed ID: 23810513
Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function.
Diabetes Dec, 2013 | Pubmed ID: 23974922
Mouse beta cell proliferation is inhibited by thymidine analogue labelling.
Diabetologia Dec, 2013 | Pubmed ID: 24026213
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
The EMBO journal Oct, 2013 | Pubmed ID: 24045232
Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes.
Diabetologia Jan, 2014 | Pubmed ID: 24121626
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
PLoS genetics Oct, 2013 | Pubmed ID: 24204325
Reversal of hyperglycemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes.
Islets Sep-Dec, 2013 | Pubmed ID: 24213480
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
Nature biotechnology Jan, 2014 | Pubmed ID: 24240391
Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.
Stem cells translational medicine Apr, 2014 | Pubmed ID: 24493854
Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells.
Stem cells and development Jun, 2014 | Pubmed ID: 24548059
IL-6-dependent proliferation of alpha cells in mice with partial pancreatic-duct ligation.
Diabetologia Jul, 2014 | Pubmed ID: 24759958
Partial duct ligation: β-cell proliferation and beyond.
Diabetes Aug, 2014 | Pubmed ID: 25060885
Clinical Immunosuppressants Inhibit Inflammatory, Proliferative And Reprogramming Potential, But Not Angiogenesis Of Human Pancreatic Duct Cells.
Cell transplantation Jul, 2014 | Pubmed ID: 25198311
In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.
Molecular and cellular endocrinology Jan, 2015 | Pubmed ID: 25224487
Combining MK626, a novel DPP-4 inhibitor, and low-dose monoclonal CD3 antibody for stable remission of new-onset diabetes in mice.
PloS one , 2014 | Pubmed ID: 25268801
Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.
European journal of immunology May, 2015 | Pubmed ID: 25645754
Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration.
Stem cells translational medicine Jun, 2015 | Pubmed ID: 25848123
Ex Vivo Expansion and Differentiation of Human and Mouse Fetal Pancreatic Progenitors Are Modulated by Epidermal Growth Factor.
Stem cells and development Aug, 2015 | Pubmed ID: 25925840
Estrogen Receptor α Regulates Beta Cell Formation During Pancreas Development and Following Injury.
Diabetes May, 2015 | Pubmed ID: 26015547
Islet Transplantation for Type 1 Diabetes: So Close and Yet So Far away.
European journal of endocrinology / European Federation of Endocrine Societies Jun, 2015 | Pubmed ID: 26036437
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