Michael D. Johnson

Kinetics and Mechanism of the Ferrate Oxidation of Thiosulfate and Other Sulfur-Containing Species.

Delayed mammary gland involution in MMTV-AKT1 transgenic mice.

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.

Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide.

The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor.

Possible role of matriptase in the diagnosis of ovarian cancer.

Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland.

Characterization of matriptase expression in normal human tissues.

Genotyping for polymorphic drug metabolizing enzymes from paraffin-embedded and immunohistochemically stained tumor samples.

Active dendritic integration of inhibitory synaptic inputs in vivo.

The kinetics and mechanism of the ferrate(VI) oxidation of hydroxylamines.

Introduction of estrogen receptor-alpha into the tTA/TAg conditional mouse model precipitates the development of estrogen-responsive mammary adenocarcinoma.

Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.

Personal characteristics, knowledge of the veterinary profession, and influences on career choice among students in the veterinary school applicant pool.

Early parity significantly elevates mammary tumor incidence in MMTV-c-myc transgenic mice.

A phase I study of oral BMS-275291, a novel nonhydroxamate sheddase-sparing matrix metalloproteinase inhibitor, in patients with advanced or metastatic cancer.

Of mice and Myc: c-Myc and mammary tumorigenesis.

Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen.

Explant-cell culture of primary mammary tumors from MMTV-c-Myc transgenic mice.

Synaptic integration in motoneurons with hyper-excitable dendrites.

Mechanistic variations in the oxidation of Piloty's acid by metal complexes.

A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer.

LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines.

Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.

HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.

GREB 1 is a critical regulator of hormone dependent breast cancer growth.

What does an orphan G-protein-coupled receptor have to do with estrogen?

Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI.

In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models.

Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells.

Reduction of vanadium(V) by L-ascorbic acid at low and neutral pH: kinetic, mechanistic, and spectroscopic characterization.

GREB1 is a novel androgen-regulated gene required for prostate cancer growth.

Reduction of lunar landing fuel requirements by utilizing lunar ballistic capture.

Multiple professional identities: examining differences in identification across work-related targets.

Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors.

MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research.

Self-exchange electron transfer in high oxidation state non-oxo metal complexes: amavadin.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin.

Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase.

Small-molecule agonists for the glucagon-like peptide 1 receptor.

Intrinsic electrical properties of spinal motoneurons vary with joint angle.

Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain.

Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome.

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.

When can employees have a family life? The effects of daily workload and affect on work-family conflict and social behaviors at home.

Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors.

Active properties of motoneurone dendrites: diffuse descending neuromodulation, focused local inhibition.

Zymogen activation, inhibition, and ectodomain shedding of matriptase.

Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.

Comparison of mouse mammary gland imaging techniques and applications: reflectance confocal microscopy, GFP imaging, and ultrasound.

A transcriptional fingerprint of estrogen in human breast cancer predicts patient survival.

Summation of excitatory and inhibitory synaptic inputs by motoneurons with highly active dendrites.

Impairment of ascorbic acid's anti-oxidant properties in confined media: inter and intramolecular reactions with air and vanadate at acidic pH.

1H NMR studies of aerosol-OT reverse micelles with alkali and magnesium counterions: preparation and analysis of MAOTs.

The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance.

Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.

Calmodulin modulates Akt activity in human breast cancer cell lines.

Toxicological analysis of low-nicotine and nicotine-free cigarettes.

Surgical versus nonsurgical management of pancreatic pseudocysts.

High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1.

Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition.

Personality and citizenship behavior: the mediating role of job satisfaction.

Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo.

Current therapies to shorten postoperative ileus.

Relationships between 25-hydroxyvitamin D levels and plasma glucose and lipid levels in pediatric outpatients.

Matriptase activation, an early cellular response to acidosis.

Evaluation of in vitro assays for assessing the toxicity of cigarette smoke and smokeless tobacco.

Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility.

TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells.

Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation.

Matriptase is involved in ErbB-2-induced prostate cancer cell invasion.

Relationships between thyroid function and lipid status or insulin resistance in a pediatric population.

Increased matriptase zymogen activation in inflammatory skin disorders.

Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.

Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats.

Altered activation patterns by triceps surae stretch reflex pathways in acute and chronic spinal cord injury.

Matriptase is inhibited by extravascular antithrombin in epithelial cells but not in most carcinoma cells.

Alternative reference points and outcome evaluation: the influence of affect.

Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing.

Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.

Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1.

Differential modulation of crossed and uncrossed reflex pathways by clonidine in adult cats following complete spinal cord injury.

Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner.

Switching off electron transfer reactions in confined media: reduction of [Co(dipic)2]- and [Co(edta)]- by hexacyanoferrate(II).

Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland.

Mechanisms of estrogen-independent breast cancer growth driven by low estrogen concentrations are unique versus complete estrogen deprivation.

Push-pull control of motor output.

Cutaneous inputs from the back abolish locomotor-like activity and reduce spastic-like activity in the adult cat following complete spinal cord injury.

Oxidation of phosphorus centers by ferrate(VI): spectral observation of an intermediate.

Nonoperative management of retrocalcaneal pain with AFO and stretching regimen.

Application of fluorescent in situ hybridization in the mouse xenograft model of human fat grafting.

Synchronous and asynchronous electrically-evoked motor activities during wind-up stimulation are differentially modulated following an acute spinal transection.

Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland.

Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility.

An integrative process model of leadership: examining loci, mechanisms, and event cycles.

Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.

Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes.

Three dimensional multiphoton imaging of fresh and whole mount developing mouse mammary glands.

Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation.

Matriptase expression and zymogen activation in human pilosebaceous unit.

Metal speciation in health and medicine represented by iron and vanadium.

A microfluidic, high throughput protein crystal growth method for microgravity.

Motoneuron intrinsic properties, but not their receptive fields, recover in chronic spinal injury.

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects.

The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniae.

Combination antiretroviral therapy (cART) component ritonavir significantly alters docetaxel exposure.

PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression.

Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activation.

Matriptase autoactivation is tightly regulated by the cellular chemical environments.

Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype.

Gain control mechanisms in spinal motoneurons.

Reconfiguration of the electrical properties of motoneurons to match the diverse demands of motor behavior.

Role of copper efflux in pneumococcal pathogenesis and resistance to macrophage-mediated immune clearance.

Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae.

Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.

Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells.

Hepatocyte Growth Factor Activator Inhibitor Type 1 Maintains the Assembly of Keratin into Desmosomes in Keratinocytes by Regulating Protease-Activated Receptor 2-Dependent p38 Signaling.