Jean-Philippe Pellois

Individually addressable parallel peptide synthesis on microchips.

Simultaneous triggering of protein activity and fluorescence.

High density peptide microarrays. In situ synthesis and applications.

A ligation and photorelease strategy for the temporal and spatial control of protein function in living cells.

Semisynthetic proteins in mechanistic studies: using chemistry to go where nature can't.

Auxiliary-mediated site-specific peptide ubiquitylation.

Tunable photoactivation of a post-translationally modified signaling protein and its unmodified counterpart in live cells.

Real-time fluorescence detection of protein transduction into live cells.

Non-covalent delivery of proteins into mammalian cells.

Live cell cytotoxicity studies: documentation of the interactions of antitumor active dirhodium compounds with nuclear DNA.

Anticancer activity of heteroleptic diimine complexes of dirhodium: a study of intercalating properties, hydrophobicity and in cellulo activity.

Delivery of macromolecules into live cells by simple co-incubation with a peptide.

Modeling of the endosomolytic activity of HA2-TAT peptides with red blood cells and ghosts.

A retro-inverso TAT-like peptide designed to deliver cysteamine to cells.

Generation of endosomolytic reagents by branching of cell-penetrating peptides: tools for the delivery of bioactive compounds to live cells in cis or trans.

Conjugation to the cell-penetrating peptide TAT potentiates the photodynamic effect of carboxytetramethylrhodamine.

A HA2-Fusion tag limits the endosomal release of its protein cargo despite causing endosomal lysis.

TAT-mediated photochemical internalization results in cell killing by causing the release of calcium into the cytosol of cells.

Photoinactivation of Gram positive and Gram negative bacteria with the antimicrobial peptide (KLAKLAK)(2) conjugated to the hydrophilic photosensitizer eosin Y.

Synergy between cell-penetrating peptides and singlet oxygen generators leads to efficient photolysis of membranes.

Photodamage of lipid bilayers by irradiation of a fluorescently labeled cell-penetrating peptide.

Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges.

Photoinduced membrane damage of E. coli and S. aureus by the photosensitizer-antimicrobial peptide conjugate eosin-(KLAKLAK)2.

The photolytic activity of poly-arginine cell penetrating peptides conjugated to carboxy-tetramethylrhodamine is modulated by arginine residue content and fluorophore conjugation site.

Protein delivery into live cells by incubation with an endosomolytic agent.

Materials composed of the Drosophila Hox protein Ultrabithorax are biocompatible and nonimmunogenic.

Optimizing the electronic properties of photoactive anticancer oxypyridine-bridged dirhodium(II,II) complexes.