Doris Kretzschmar

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing.

Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap.

Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.

Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.

The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration.

Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila.

Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila.

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.

Neurodegenerative mutants in Drosophila: a means to identify genes and mechanisms involved in human diseases?

Optomotor-blind expression in glial cells is required for correct axonal projection across the Drosophila inner optic chiasm.

Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.

Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function.

Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila.

Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration.

The circadian clock gene period extends healthspan in aging Drosophila melanogaster.

Alzheimer's disease and tauopathy studies in flies and worms.

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.

Analysis of amyloid precursor protein function in Drosophila melanogaster.

Drosophila GGA model: an ultimate gateway to GGA analysis.

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.

Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.

Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration.

β-secretase cleavage of the fly amyloid precursor protein is required for glial survival.

Mutations in γ adducin are associated with inherited cerebral palsy.

Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.

Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig.

Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.

Relationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila.

Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.

Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.

Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster.

Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.