Oregon Institute of Occupational Health Sciences
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The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing.
The EMBO journal Dec, 2002 | Pubmed ID: 12456644
Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap.
Molecular biology of the cell Jan, 2003 | Pubmed ID: 12529440
Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice.
Molecular and cellular biology Feb, 2004 | Pubmed ID: 14749382
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience Apr, 2004 | Pubmed ID: 15102905
The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration.
Current biology : CB May, 2004 | Pubmed ID: 15120069
Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila.
Glia Jan, 2005 | Pubmed ID: 15390099
Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila.
Molecular biology of the cell May, 2005 | Pubmed ID: 15772149
Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2005 | Pubmed ID: 15772346
Neurodegenerative mutants in Drosophila: a means to identify genes and mechanisms involved in human diseases?
Invertebrate neuroscience : IN Nov, 2005 | Pubmed ID: 16187075
Optomotor-blind expression in glial cells is required for correct axonal projection across the Drosophila inner optic chiasm.
Developmental biology Mar, 2008 | Pubmed ID: 18234176
Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2008 | Pubmed ID: 18945896
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function.
Neurobiology of disease Feb, 2009 | Pubmed ID: 19049874
Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila.
Journal of neurogenetics , 2009 | Pubmed ID: 19132601
Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration.
Journal of neuroscience research Jul, 2010 | Pubmed ID: 20143421
The circadian clock gene period extends healthspan in aging Drosophila melanogaster.
Aging Nov, 2009 | Pubmed ID: 20157575
Alzheimer's disease and tauopathy studies in flies and worms.
Neurobiology of disease Oct, 2010 | Pubmed ID: 20302939
A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.
Disease models & mechanisms Sep, 2011 | Pubmed ID: 21596710
Analysis of amyloid precursor protein function in Drosophila melanogaster.
Experimental brain research Apr, 2012 | Pubmed ID: 21912928
Drosophila GGA model: an ultimate gateway to GGA analysis.
Traffic (Copenhagen, Denmark) Dec, 2011 | Pubmed ID: 21923734
Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.
Neurobiology of disease Mar, 2012 | Pubmed ID: 22227001
Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.
Neurobiology of disease Apr, 2012 | Pubmed ID: 22266106
Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration.
PloS one , 2012 | Pubmed ID: 22970217
β-secretase cleavage of the fly amyloid precursor protein is required for glial survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2012 | Pubmed ID: 23152602
Mutations in γ adducin are associated with inherited cerebral palsy.
Annals of neurology Dec, 2013 | Pubmed ID: 23836506
Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.
PloS one , 2014 | Pubmed ID: 24558370
Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig.
PloS one , 2014 | Pubmed ID: 24587072
Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.
Developmental neurobiology Dec, 2014 | Pubmed ID: 24909306
Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.
The Journal of clinical endocrinology and metabolism Oct, 2014 | Pubmed ID: 25033069
Relationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila.
PloS one , 2014 | Pubmed ID: 25171136
Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.
Neurobiology of disease May, 2015 | Pubmed ID: 25766673
Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.
Disease models & mechanisms Mar, 2016 | Pubmed ID: 26634819
Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster.
Frontiers in molecular neuroscience , 2016 | Pubmed ID: 27507933
Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.
Frontiers in molecular neuroscience , 2016 | Pubmed ID: 27932950
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