Alan N. Schechter

An immunologic approach to the conformational equilibria of polypeptides.

Folding of staphylococcal nuclease: magnetic resonance and fluorescence studies of individual residues.

The active site of staphylococcal nuclease: paramagnetic relaxation of bound nucleotide inhibitor nuclei by lanthanide ions.

Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity.

Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation.

Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans.

Quantitative analysis of globin gene induction in single human erythroleukemic cells.

Prematurity in gene therapy.

S-Nitrosohemoglobin is unstable in the reductive erythrocyte environment and lacks O2/NO-linked allosteric function.

Sickle Hb polymerization in RBC components from donors with sickle cell trait prevents effective WBC reduction by filtration.

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease.

Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase.

Divergent nitric oxide bioavailability in men and women with sickle cell disease.

Red blood cell magnetophoresis.

Hemoglobin and the paracrine and endocrine functions of nitric oxide.

Nitric oxide's reactions with hemoglobin: a view through the SNO-storm.

Identification and characterization of mechanistically distinct inducers of gamma-globin transcription.

Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation.

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.

Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells.

Increasing hemoglobin oxygen saturation levels in sickle trait donor whole blood prevents hemoglobin S polymerization and allows effective white blood cell reduction by filtration.

Linderstrom-Lang-Schellman's model for protein stabilization revisited.

Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator.

Why is revitalizing clinical research so important, yet so difficult?

Erythrocytes are the major intravascular storage sites of nitrite in human blood.

Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.

The emerging biology of the nitrite anion.

Fetal hemoglobin silencing in humans.

The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions.

Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability.

Randomization in clinical trials of titrated therapies: unintended consequences of using fixed treatment protocols.

Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation.

Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes.

Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells.

The reaction between nitrite and oxyhemoglobin: a mechanistic study.

Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes.

Hemoglobin research and the origins of molecular medicine.

The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies.

Evidence-based medicine again.

Stimulated stromal cells induce gamma-globin gene expression in erythroid cells via nitric oxide production.

Translational medicine--doing it backwards.

Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay.

Erythropoietin and hypoxia increase erythropoietin receptor and nitric oxide levels in lung microvascular endothelial cells.

Acute erythropoietin cardioprotection is mediated by endothelial response.

Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits.

Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation.

Inorganic nitrate: a major player in the cardiovascular health benefits of vegetables?

JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny.

Effect of storage on levels of nitric oxide metabolites in platelet preparations.

Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.

Comments on 'vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway'.

Effect of blood nitrite and nitrate levels on murine platelet function.

Globin gene expression in correlation with G protein-related genes during erythroid differentiation.

In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines.

Increased reticulocytosis during infancy is associated with increased hospitalizations in sickle cell anemia patients during the first three years of life.

Effect of storage levels of nitric oxide derivatives in blood components.

A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes.

Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions.

Construction of effective disposable biosensors for point of care testing of nitrite.

Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the mTOR Signaling Pathway.

Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle.

Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension.

Angiogenic factors are increased in circulating granulocytes and CD34(+) cells of myeloproliferative neoplasms.

Acid Test for Nitrite Pharmacology.

Skeletal and myocardial microvascular blood flow in hydroxycarbamide-treated patients with sickle cell disease.

Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia.

Effect of dietary nitrate levels on nitrate fluxes in rat skeletal muscle and liver.

Phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) in platelets is increased by nitrite and partially deoxygenated erythrocytes.

Decreased nitrite reductase activity of deoxyhemoglobin correlates with platelet activation in hemoglobin E/ß-thalassemia subjects.

Airlie House legend.

Compensatory mechanisms in myoglobin deficient mice preserve NO homeostasis.

Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension.

Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise.

Nitrate uptake and metabolism in human skeletal muscle cell cultures.

Potential roles of nitrate and nitrite in nitric oxide metabolism in the eye.

Control of rat muscle nitrate levels after perturbation of steady state dietary nitrate intake.