Department of Biology - Skeletal Research Center
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The STRO-1+ marrow cell population is multipotential.
Cells, tissues, organs , 2002 | Pubmed ID: 11731697
Treatment of osteochondral defects with autologous bone marrow in a hyaluronan-based delivery vehicle.
Tissue engineering Apr, 2002 | Pubmed ID: 12031121
In vivo remodeling.
Annals of the New York Academy of Sciences Jun, 2002 | Pubmed ID: 12081925
In vivo remodeling: breakout session summary.
Annals of the New York Academy of Sciences Jun, 2002 | Pubmed ID: 12081929
Immunochemical and mechanical characterization of cartilage subtypes in rabbit.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Aug, 2002 | Pubmed ID: 12133908
Bioreactors mediate the effectiveness of tissue engineering scaffolds.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2002 | Pubmed ID: 12207008
Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge.
Tissue engineering Oct, 2002 | Pubmed ID: 12459061
Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin.
The Journal of biological chemistry May, 2003 | Pubmed ID: 12621051
Embryonic development and the principles of tissue engineering.
Novartis Foundation symposium , 2003 | Pubmed ID: 12708647
Production of a monoclonal antibody, DF-5, that identifies cells at the epithelial-mesenchymal interface in normal human skin. APN/CD13 is an epithelial-mesenchymal marker in skin.
Experimental dermatology Jun, 2003 | Pubmed ID: 12823446
Cytokines and glucocorticoids differentially regulate APN/CD13 and DPPIV/CD26 enzyme activities in cultured human dermal fibroblasts.
Archives of dermatological research Aug, 2003 | Pubmed ID: 12861419
Fibroblast heterogeneity: more than skin deep.
Journal of cell science Feb, 2004 | Pubmed ID: 14754903
Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material.
Orthopedics Jan, 2004 | Pubmed ID: 14763552
Targeted delivery of progenitor cells for cartilage repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jul, 2004 | Pubmed ID: 15183428
A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential.
The Journal of experimental medicine Jul, 2004 | Pubmed ID: 15263023
Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype.
Methods in molecular medicine , 2004 | Pubmed ID: 15280587
Adult stem cell driven genesis of human-shaped articular condyle.
Annals of biomedical engineering Jul, 2004 | Pubmed ID: 15298429
Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells.
Journal of cellular physiology Apr, 2005 | Pubmed ID: 15389636
Osteochondral defect repair by demineralized cortical bone matrix.
Clinical orthopaedics and related research Oct, 2004 | Pubmed ID: 15480077
FGF-2 enhances the mitotic and chondrogenic potentials of human adult bone marrow-derived mesenchymal stem cells.
Journal of cellular physiology May, 2005 | Pubmed ID: 15521064
Controlled release of hyaluronan oligomers from biodegradable polymeric microparticle carriers.
Journal of controlled release : official journal of the Controlled Release Society Nov, 2004 | Pubmed ID: 15544873
Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system.
Tissue engineering Nov-Dec, 2004 | Pubmed ID: 15684678
Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds.
Osteoarthritis and cartilage Apr, 2005 | Pubmed ID: 15780643
Effect of transforming growth factor beta 2 on marrow-infused foam poly(propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits.
Tissue engineering May-Jun, 2005 | Pubmed ID: 15998232
Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics.
Tissue engineering Jul-Aug, 2005 | Pubmed ID: 16144456
A simple method for stem cell labeling with fluorine 18.
Nuclear medicine and biology Oct, 2005 | Pubmed ID: 16243645
Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54.
Journal of cellular physiology May, 2006 | Pubmed ID: 16331675
Mesenchymal stem cells as trophic mediators.
Journal of cellular biochemistry Aug, 2006 | Pubmed ID: 16619257
A rapid seeding technique for the assembly of large cell/scaffold composite constructs.
Tissue engineering Jul, 2006 | Pubmed ID: 16889515
Toxic effects of gentamicin on marrow-derived human mesenchymal stem cells.
Clinical orthopaedics and related research Nov, 2006 | Pubmed ID: 16906089
Isolation of human marrow-derived mesenchymal stem cells.
Experimental hematology Nov, 2006 | Pubmed ID: 17046583
Isolation of rat marrow-derived mesenchymal stem cells.
Experimental hematology Nov, 2006 | Pubmed ID: 17046584
Clonal characterization of fibroblasts in the superficial layer of the adult human dermis.
Cell and tissue research Mar, 2007 | Pubmed ID: 17093925
Human mesenchymal stem cells signals regulate neural stem cell fate.
Neurochemical research Feb, 2007 | Pubmed ID: 17191131
Cartilage tissue engineering for laryngotracheal reconstruction: comparison of chondrocytes from three anatomic locations in the rabbit.
Tissue engineering Apr, 2007 | Pubmed ID: 17394383
Isolation and characterization of a population of immature dental pulp stem cells expressing OCT-4 and other embryonic stem cell markers.
Cells, tissues, organs , 2006 | Pubmed ID: 17409736
Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering.
Biomaterials Jul, 2007 | Pubmed ID: 17445882
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.
Journal of cellular physiology Nov, 2007 | Pubmed ID: 17620285
A self-assembled fibroblast-endothelial cell co-culture system that supports in vitro vasculogenesis by both human umbilical vein endothelial cells and human dermal microvascular endothelial cells.
Cells, tissues, organs , 2007 | Pubmed ID: 17657137
Human dermal fibroblast subpopulations; differential interactions with vascular endothelial cells in coculture: nonsoluble factors in the extracellular matrix influence interactions.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Mar-Apr, 2008 | Pubmed ID: 18318814
Effect of dual growth factor delivery on chondrogenic differentiation of rabbit marrow mesenchymal stem cells encapsulated in injectable hydrogel composites.
Journal of biomedical materials research. Part A Mar, 2009 | Pubmed ID: 18381637
In search of the in vivo identity of mesenchymal stem cells.
Stem cells (Dayton, Ohio) Sep, 2008 | Pubmed ID: 18566331
Effects of initial seeding density and fluid perfusion rate on formation of tissue-engineered bone.
Tissue engineering. Part A Nov, 2008 | Pubmed ID: 18620487
Dexamethasone inhibition of confluence-induced apoptosis in human mesenchymal stem cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Feb, 2009 | Pubmed ID: 18683880
All MSCs are pericytes?
Cell stem cell Sep, 2008 | Pubmed ID: 18786406
MSC frequency correlates with blood vessel density in equine adipose tissue.
Tissue engineering. Part A Feb, 2009 | Pubmed ID: 18847356
In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jul, 2009 | Pubmed ID: 19137580
Effect of swelling ratio of injectable hydrogel composites on chondrogenic differentiation of encapsulated rabbit marrow mesenchymal stem cells in vitro.
Biomacromolecules Mar, 2009 | Pubmed ID: 19173557
Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis.
Glia Aug, 2009 | Pubmed ID: 19191336
Influence of adult mesenchymal stem cells on in vitro vascular formation.
Tissue engineering. Part A Jul, 2009 | Pubmed ID: 19196139
New era of cell-based orthopedic therapies.
Tissue engineering. Part B, Reviews Jun, 2009 | Pubmed ID: 19228082
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.
Nature medicine Mar, 2009 | Pubmed ID: 19234460
Fibroblasts-a diverse population at the center of it all.
International review of cell and molecular biology , 2009 | Pubmed ID: 19584013
Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix.
Tissue engineering. Part A Feb, 2010 | Pubmed ID: 19715387
Optimizing mesenchymal stem cell-based therapeutics.
Current opinion in biotechnology Oct, 2009 | Pubmed ID: 19783424
Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells.
Tissue engineering. Part A Mar, 2010 | Pubmed ID: 19842915
Mechanisms involved in the therapeutic properties of mesenchymal stem cells.
Cytokine & growth factor reviews Oct-Dec, 2009 | Pubmed ID: 19926330
Low oxygen tension during incubation periods of chondrocyte expansion is sufficient to enhance postexpansion chondrogenesis.
Tissue engineering. Part A May, 2010 | Pubmed ID: 19958052
In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds.
Biomaterials Mar, 2010 | Pubmed ID: 20034665
The potential of mesenchymal stem cells for neural repair.
Discovery medicine Mar, 2010 | Pubmed ID: 20350491
What's in a name?
Tissue engineering. Part A Aug, 2010 | Pubmed ID: 20412005
Adult mesenchymal stem cells: an innovative therapeutic for lung diseases.
Discovery medicine Apr, 2010 | Pubmed ID: 20423678
Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds.
Tissue engineering. Part A Dec, 2010 | Pubmed ID: 20673022
Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model.
American journal of physiology. Lung cellular and molecular physiology Dec, 2010 | Pubmed ID: 20817776
Topical delivery of mesenchymal stem cells and their function in wounds.
Stem cell research & therapy Sep, 2010 | Pubmed ID: 20863417
Age-related differences in human skin proteoglycans.
Glycobiology Feb, 2011 | Pubmed ID: 20947661
Defining human mesenchymal stem cell efficacy in vivo.
Journal of inflammation (London, England) Oct, 2010 | Pubmed ID: 20974000
Mesenchymal stem cells: mechanisms of inflammation.
Annual review of pathology , 2011 | Pubmed ID: 21073342
2010 lifetime achievement award of Tissue Engineering and Regenerative Medicine International Society--north America: Arnold I. Caplan, Ph.D.
Tissue engineering. Part A Feb, 2011 | Pubmed ID: 21128820
Biological evaluation of a new C-xylopyranoside derivative (C-Xyloside) and its role in glycosaminoglycan biosynthesis.
European journal of dermatology : EJD May-Jun, 2011 | Pubmed ID: 21609902
PDGF in bone formation and regeneration: new insights into a novel mechanism involving MSCs.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Dec, 2011 | Pubmed ID: 21618276
The MSC: an injury drugstore.
Cell stem cell Jul, 2011 | Pubmed ID: 21726829
Nondestructive evaluation of hydrogel mechanical properties using ultrasound.
Annals of biomedical engineering Oct, 2011 | Pubmed ID: 21773854
Polybrene inhibits human mesenchymal stem cell proliferation during lentiviral transduction.
PloS one , 2011 | Pubmed ID: 21887340
The creation of an in vitro adipose tissue that contains a vascular-adipocyte complex.
Biomaterials Dec, 2011 | Pubmed ID: 21959010
Stem cells in dental pulp of deciduous teeth.
Tissue engineering. Part B, Reviews Apr, 2012 | Pubmed ID: 22032258
Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell.
Journal of drug targeting Jan, 2012 | Pubmed ID: 22047107
Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition.
The Biochemical journal Apr, 2012 | Pubmed ID: 22257180
Imaging stem cell differentiation for cell-based tissue repair.
Methods in enzymology , 2012 | Pubmed ID: 22341228
Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models.
Nature neuroscience Jun, 2012 | Pubmed ID: 22610068
Quantitative microscopy in murine models of lung inflammation.
Analytical and quantitative cytology and histology Oct, 2011 | Pubmed ID: 22611751
Scaling-up of dental pulp stem cells isolated from multiple niches.
PloS one , 2012 | Pubmed ID: 22768154
The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds.
Biomaterials Dec, 2012 | Pubmed ID: 22999467
Cell transplantation as an initiator of endogenous stem cell-based tissue repair.
Current opinion in organ transplantation Dec, 2012 | Pubmed ID: 23111645
Micrometer scale guidance of mesenchymal stem cells to form structurally oriented cartilage extracellular matrix.
Tissue engineering. Part A May, 2013 | Pubmed ID: 23157410
The effect of extended first passage culture on the proliferation and differentiation of human marrow-derived mesenchymal stem cells.
Stem cells translational medicine Apr, 2012 | Pubmed ID: 23197807
Efficient lentiviral transduction of human mesenchymal stem cells that preserves proliferation and differentiation capabilities.
Stem cells translational medicine Dec, 2012 | Pubmed ID: 23283550
Adult mesenchymal stem cells and the NO pathways.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2013 | Pubmed ID: 23396846
Growth, differentiation capacity, and function of mesenchymal stem cells expanded in serum-free medium developed via combinatorial screening.
Experimental cell research Jun, 2013 | Pubmed ID: 23597555
The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of MSCs.
Biomaterials Jul, 2013 | Pubmed ID: 23642532
MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation.
Stem cells international , 2013 | Pubmed ID: 24000286
Mesenchymal stem cells in tissue repair.
Frontiers in immunology Sep, 2013 | Pubmed ID: 24027567
Serial transplantation and long-term engraftment of intra-arterially delivered clonally derived mesenchymal stem cells to injured bone marrow.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2014 | Pubmed ID: 24067545
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine.
Experimental & molecular medicine Nov, 2013 | Pubmed ID: 24232253
Validating continuous digital light processing (cDLP) additive manufacturing accuracy and tissue engineering utility of a dye-initiator package.
Biofabrication Mar, 2014 | Pubmed ID: 24429508
Progressive approval: a proposal for a new regulatory pathway for regenerative medicine.
Stem cells translational medicine May, 2014 | Pubmed ID: 24682285
Chondrogenic differentiation of mesenchymal stem cells: challenges and unfulfilled expectations.
Tissue engineering. Part B, Reviews Dec, 2014 | Pubmed ID: 24749845
The role of CXCL12 and CCL7 chemokines in immune regulation, embryonic development, and tissue regeneration.
Cytokine Oct, 2014 | Pubmed ID: 25034237
Identification of a subpopulation of marrow MSC-derived medullary adipocytes that express osteoclast-regulating molecules: marrow adipocytes express osteoclast mediators.
PloS one , 2014 | Pubmed ID: 25302610
Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance.
Cancer research Mar, 2015 | Pubmed ID: 25604264
Adult mesenchymal stem cells and women's health.
Menopause (New York, N.Y.) Feb, 2015 | Pubmed ID: 25608271
Regenerative treatments to enhance orthopedic surgical outcome.
PM & R : the journal of injury, function, and rehabilitation Apr, 2015 | Pubmed ID: 25864660
Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells.
Stem cells (Dayton, Ohio) Sep, 2015 | Pubmed ID: 26013357
Body Management: Mesenchymal Stem Cells Control the Internal Regenerator.
Stem cells translational medicine Jul, 2015 | Pubmed ID: 26019227
Mesenchymal Stem Cells: The Past, the Present, the Future.
Cartilage Jan, 2010 | Pubmed ID: 26069532
The MSC curtain that stops the immune system.
Immunology letters Dec, 2015 | Pubmed ID: 26079607
Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche.
International journal of cancer Jan, 2016 | Pubmed ID: 26235173
Adult Mesenchymal Stem Cells: When, Where, and How.
Stem cells international , 2015 | Pubmed ID: 26273305
Mesenchymal stem cell therapy in a rat model of birth-trauma injury: functional improvements and biodistribution.
International urogynecology journal Feb, 2016 | Pubmed ID: 26353846
Proteoglycans in Leiomyoma and Normal Myometrium: Abundance, Steroid Hormone Control, and Implications for Pathophysiology.
Reproductive sciences (Thousand Oaks, Calif.) Mar, 2016 | Pubmed ID: 26423601
MSCs: The Sentinel and Safe-Guards of Injury.
Journal of cellular physiology Jul, 2016 | Pubmed ID: 26565391
Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment.
Stem cells international , 2016 | Pubmed ID: 26925108
Development of a Functional Biomarker for Use in Cell-Based Therapy Studies in Seropositive Rheumatoid Arthritis.
Stem cells translational medicine May, 2016 | Pubmed ID: 27025689
Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27236668
The 3Rs of Cell Therapy.
Stem cells translational medicine Aug, 2016 | Pubmed ID: 27502516
Growth Factor Dose Tuning for Bone Progenitor Cell Proliferation and Differentiation on Resorbable Poly(propylene fumarate) Scaffolds.
Tissue engineering. Part C, Methods Sep, 2016 | Pubmed ID: 27558310
The 3Rs of Cell Therapy.
Stem cells translational medicine Jan, 2017 | Pubmed ID: 28170173
New MSC: MSCs as pericytes are Sentinels and gatekeepers.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Jun, 2017 | Pubmed ID: 28294393
Mesenchymal Stem Cells: Time to Change the Name!
Stem cells translational medicine Jun, 2017 | Pubmed ID: 28452204
Not Missing the Future: A Call to Action for Investigating the Role of Regenerative Medicine Therapies in Pediatric/Adolescent Sports Injuries.
Current sports medicine reports May/Jun, 2017 | Pubmed ID: 28498229
Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage.
Tissue engineering. Part A Jul, 2017 | Pubmed ID: 28602122
Non-destructive/non-invasive imaging evaluation of cellular differentiation progression during in vitro MSC-derived chondrogenesis.
Tissue engineering. Part A Aug, 2017 | Pubmed ID: 28825369
Maneesh Dave1,
Paola Menghini1,
Keiki Sugi2,3,
Rodrigo A. Somoza5,
Zhenghong Lee4,
Mukesh Jain2,3,
Arnold Caplan5,
Fabio Cominelli1
1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University,
2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University,
3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center,
4Department of Radiology, University Hospitals Case Medical Center,
5Department of Biology - Skeletal Research Center, Case Western Reserve University
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