James Fraser

Venous protocols, techniques, and interpretations of the upper and lower extremities.

A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells.

PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans.

Coherent vibrational climbing in carboxyhemoglobin.

Improving treatment services for substance abusers with comorbid depression.

Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms.

Detubulation abolishes membrane potential stabilization in amphibian skeletal muscle.

Detubulation experiments localise delayed rectifier currents to the surface membrane of amphibian skeletal muscle fibres.

2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.

The effect of intracellular acidification on the relationship between cell volume and membrane potential in amphibian skeletal muscle.

Slow volume transients in amphibian skeletal muscle fibres studied in hypotonic solutions.

The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.

Chromosomal translocation and segmental duplication in Cryptococcus neoformans.

Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity.

Deciphering the model pathogenic fungus Cryptococcus neoformans.

Chromosomal sex-determining regions in animals, plants and fungi.

Nuclear accumulation of the GATA factor AreA in response to complete nitrogen starvation by regulation of nuclear export.

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak.

Effect of repetitive stimulation on cell volume and its relationship to membrane potential in amphibian skeletal muscle.

The influence of intracellular lactate and H+ on cell volume in amphibian skeletal muscle.

Ig-like domains on bacteriophages: a tale of promiscuity and deceit.

Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale.

Parametric cascade downconverter for intense ultrafast mid-infrared generation beyond the Manley-Rowe limit.

Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment.

Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle.

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Pyridine-2-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents.

Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells.

Membrane potentials in Rana temporaria muscle fibres in strongly hypertonic solutions.

Quantitative techniques for steady-state calculation and dynamic integrated modelling of membrane potential and intracellular ion concentrations.

Heat-induced dimerization of BCL-xL through alpha-helix swapping.

The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts.

Alterations in triad ultrastructure following repetitive stimulation and intracellular changes associated with exercise in amphibian skeletal muscle.

Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii.

A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts.

Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood.

An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak.

Immunoglobulin-like domains on bacteriophage: weapons of modest damage?

Birnbaum LM, Filion KB, Joyal D, Eisenberg MJ. Second reading of coronary angiograms by radiologists. Can J Cardiol 2006;22(14):1217-1221.

Biochemical signal detection in miniaturized fluidic systems by integrated microresonator.

Time-gated Fourier-domain optical coherence tomography.

Similarities and contrasts in ryanodine receptor localization and function in osteoclasts and striated muscle cells.

Extracellular charge adsorption influences intracellular electrochemical homeostasis in amphibian skeletal muscle.

Translational imaging studies of cortical spreading depression in experimental models for migraine aura.

Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans.

Pharmacological characterization of a small molecule inhibitor of c-Jun kinase.

Control of cell volume in skeletal muscle.

Sexual reproduction and dimorphism in the pathogenic basidiomycetes.

Contrast improvement in Fourier-domain optical coherence tomography through time gating.

Accidental ingestion of dosulepin presenting as atrial flutter in a child.

Chromatin conformation signatures of cellular differentiation.

High speed in situ depth profiling of ultrafast micromachining.

Prevalence of antibodies to West Nile virus and other arboviruses among Crested Caracaras (Caracara cheriway) in Florida.

Hidden alternative structures of proline isomerase essential for catalysis.

In situ 24 kHz coherent imaging of morphology change in laser percussion drilling.

Saturation of the photoluminescence at few-exciton levels in a single-walled carbon nanotube under ultrafast excitation.

Comprehensive management of hot-press hand injuries: long-term outcomes following reconstruction and rehabilitation.

America's fertile frontier: how America surpassed Britain in the development and growth of plastic surgery during the interwar years of 1920-1940.

Automated electron-density sampling reveals widespread conformational polymorphism in proteins.

Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus.

Computing chromosome conformation.

The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling.

Mining electron density for functionally relevant protein polysterism in crystal structures.

The underwater photic environment of Cape Maclear, Lake Malawi: comparison between rock- and sand-bottom habitats and implications for cichlid fish vision.

Repetitive flood victims and acceptance of FEMA mitigation offers: an analysis with community-system policy implications.

Increasing prevalence of domiciliary ventilation: changes in service demand and provision in the South West of the UK.

Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.

Relationships between resting conductances, excitability, and t-system ionic homeostasis in skeletal muscle.

An analysis of the relationships between subthreshold electrical properties and excitability in skeletal muscle.

A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients.

Accessing protein conformational ensembles using room-temperature X-ray crystallography.

Reciprocal dihydropyridine and ryanodine receptor interactions in skeletal muscle activation.

Three-dimensional modeling of chromatin structure from interaction frequency data using Markov chain Monte Carlo sampling.

Dimethyl sulphoxide addition or withdrawal causes biphasic volume changes and its withdrawal causes t-system vacuolation in skeletal muscle.

Real-time guidance of thermal and ultrashort pulsed laser ablation in hard tissue using inline coherent imaging.

Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome.

Microevolution of Cryptococcus neoformans driven by massive tandem gene amplification.

Quantifying and comparing torsional strains after olecranon plating.

Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex.

A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence.

Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair.

Characterization of an Nmr homolog that modulates GATA factor-mediated nitrogen metabolite repression in Cryptococcus neoformans.

Anti-interleukin-10R1 monoclonal antibody enhances bacillus Calmette-Guérin induced T-helper type 1 immune responses and antitumor immunity in a mouse orthotopic model of bladder cancer.

Systematic functional prioritization of protein posttranslational modifications.

A Torrent of data: mapping chromatin organization using 5C and high-throughput sequencing.

CheShift-2 resolves a local inconsistency between two X-ray crystal structures.

Convergent adaptations: bitter manioc cultivation systems in fertile anthropogenic dark earths and floodplain soils in Central Amazonia.

In support of the BMRB.

Complexity of chromatin folding is captured by the strings and binders switch model.

De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.

Conduction slowing contributes to spontaneous ventricular arrhythmias in intrinsically active murine RyR2-P2328S hearts.

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

From systems to structure: bridging networks and mechanism.

Ploidy variation as an adaptive mechanism in human pathogenic fungi.

Flexible backbone sampling methods to model and design protein alternative conformations.

A model of the large-scale organization of chromatin.

Appropriateness of imaging in Canada.

Comparative Genomics of Serial Isolates of Cryptococcus neoformans Reveals Gene Associated With Carbon Utilization and Virulence.

Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway.

Extracellular magnesium and calcium reduce myotonia in ClC-1 inhibited rat muscle.

Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans.

Nitrogen regulation of virulence in clinically prevalent fungal pathogens.

Deep nonlinear ablation of silicon with a quasi-continuous wave fiber laser at 1070 nm.

Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.

"It's common sense that it's wrong": young people's perceptions and experiences of cyberbullying.

Phase I dose escalation study of bortezomib in combination with lenalidomide in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).

Is the nickel-dependent urease complex of Cryptococcus the pathogen's Achilles' heel?

A polymer model explains the complexity of large-scale chromatin folding.

Determinants of myocardial conduction velocity: implications for arrhythmogenesis.

Secondary metabolites of the sponge-derived fungus Acremonium persicinum.

Automated identification of functional dynamic contact networks from X-ray crystallography.

From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.

The SCN5A mutation A1180V is associated with electrocardiographic features of LQT3.

Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans.

Improving the practice of child death overview panels: a paediatric perspective.

Repurposing CRISPR/Cas9 for in situ functional assays.

Balancing stability and flexibility within the genome of the pathogen Cryptococcus neoformans.

Protein structural ensembles are revealed by redefining X-ray electron density noise.

Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR.

Functional consequences of NKCC2 splice isoforms: insights from a Xenopus oocyte model.

Diffuse X-ray scattering to model protein motions.

Antimicrobial distribution from local delivery depends on dose : a pilot study with MRI.

A conceptual model of the role of complexity in the care of patients with multiple chronic conditions.

Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA.

Teaching and physics education research: bridging the gap.

Measurement and interpretation of electrocardiographic QT intervals in murine hearts.

Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.

Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.

Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR.

Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery.

Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.

E pluribus unum, no more: from one crystal, many conformations.

Increased transfusion-free survival following auxiliary pig liver xenotransplantation.

Child death in high-income countries.

Learning from child death review in the USA, England, Australia, and New Zealand.

Patterns of child death in England and Wales.

Understanding why children die in high-income countries.

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.

The determinants of transverse tubular volume in resting skeletal muscle.

Conformational dynamics of a crystalline protein from microsecond-scale molecular dynamics simulations and diffuse X-ray scattering.

The Gown-glove Interface Is a Source of Contamination: A Comparative Study.

Wear and loosening in total knee arthroplasty: a quick review.

Keep on moving: discovering and perturbing the conformational dynamics of enzymes.

Differential regenerative capacity of neonatal mouse hearts after cryoinjury.

Integrative, dynamic structural biology at atomic resolution--it's about time.

A genomic safe haven for mutant complementation in Cryptococcus neoformans.

Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.

Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.

One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.

Complete Genome Sequence of Sporisorium scitamineum and Biotrophic Interaction Transcriptome with Sugarcane.

An Overview of Genome Organization and How We Got There: from FISH to Hi-C.

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles.

From deep TLS validation to ensembles of atomic models built from elemental motions.

EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.

Flemingin-Type Prenylated Chalcones from the Sarawak Rainforest Plant Desmodium congestum.

Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation.

Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit.

The RyR2-P2328S mutation downregulates Nav1.5 producing arrhythmic substrate in murine ventricles.

The morbidity and mortality meeting: time for a different approach?

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation.

Automated 3D bone ablation with 1,070 nm ytterbium-doped fiber laser enabled by inline coherent imaging.

Antibacterial and antifungal screening of natural products sourced from Australian fungi and characterisation of pestalactams D-F.

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.

Whole Genome Comparison Reveals High Levels of Inbreeding and Strain Redundancy Across the Spectrum of Commercial Wine Strains of Saccharomyces cerevisiae.

High-density grids for efficient data collection from multiple crystals.

Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase.

Data publication with the structural biology data grid supports live analysis.

Metapopulation viability of an endangered shorebird depends on dispersal and human-created habitats: piping plovers (Charadrius melodus) and prairie rivers.

Measuring and modeling diffuse scattering in protein X-ray crystallography.

Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting.

Benchmarking in Australia using the International Foundations of Medicine Clinical Science Examination.

SCIENTIFIC COMMUNITY. Preprints for the life sciences.

The Halo Effect: An Unintended Benefit of Care Pathways.

Patient Perception of Value in Bundled Payments for Total Joint Arthroplasty.

International Rates of Patellar Resurfacing in Primary Total Knee Arthroplasty, 2004-2014.

From deep TLS validation to ensembles of atomic models built from elemental motions. Addenda and corrigendum.

Calculating the Cost and Risk of Comorbidities in Total Joint Arthroplasty in the United States.

Determining crystal structures through crowdsourcing and coursework.

Chemical Inhibitors of Non-Homologous End Joining Increase Targeted Construct Integration in Cryptococcus neoformans.

Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta.

Targeted Genome Editing via CRISPR in the Pathogen Cryptococcus neoformans.

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Corrigendum: Determining crystal structures through crowdsourcing and coursework.

Men with Duchenne muscular dystrophy and end of life planning.

Cell-type-specific expression of NFIX in the developing and adult cerebellum.

Immunogenicity of a peptide-based anti-IgE conjugate vaccine in non-human primates.

Conformational variation of proteins at room temperature is not dominated by radiation damage.

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.

The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements.

QUESTION 2: Does prophylactic nystatin prevent invasive fungal infections in immunocompetent critically ill children on broad-spectrum antibiotics?

Complex multi-enhancer contacts captured by genome architecture mapping.

Calcium-dependent Nedd4-2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure.