Max Gassmann

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.

Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line.

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin.

From Genetically Altered Mice to Integrative Physiology.

Physiologically low oxygen concentrations in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor-beta3.

Copper ion redox state is critical for its effects on ion transport pathways and methaemoglobin formation in trout erythrocytes.

Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression.

Rescue of hypoxia-inducible factor-1alpha-deficient tumor growth by wild-type cells is independent of vascular endothelial growth factor.

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration.

Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin.

Extracellular signal-regulated protein kinase activation during reoxygenation is required to restore ischaemia-induced endothelial barrier failure.

DNA-binding activity of hypoxia-inducible factors (HIFs).

Pattern of prepro-endothelin-1 expression revealed by reporter-gene activity in kidneys of erythropoietin-overexpressing mice.

Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors.

Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells.

Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis.

Hypoxic up-regulation of erythroid 5-aminolevulinate synthase.

Characterization of HIF-1 alpha overexpressing HeLa cells and implications for gene therapy.

Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy.

Erythropoietin-induced excessive erythrocytosis activates the tissue endothelin system in mice.

Ultrasound guided, pre-radiation oxygen measurements using polarographic oxygen needle electrodes in spontaneous canine soft tissue sarcomas.

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species.

Hemostasis and coagulation at a hematocrit level of 0.85: functional consequences of erythrocytosis.

Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity.

Defective brain development in mice lacking the Hif-1alpha gene in neural cells.

Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN.

Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5.

Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure.

Molecular mechanisms of oxygen-induced regulation of Na+/K+ pump.

Hypoxia and high altitude. The molecular response.

Non-erythroid functions of erythropoietin.

Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis.

HIFs and tumors--causes and consequences.

Differentiating embryonic stem cells into embryoid bodies.

Oxygenation of spontaneous canine tumors during fractionated radiation therapy.

Simultaneous exposure of rats to dioxin and carbon monoxide reduces the xenobiotic but not the hypoxic response.

Rescue of lethal c-KitW/W mice by erythropoietin.

Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis.

Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration.

High altitude training of dogs results in elevated erythropoietin and endothelin-1 serum levels.

Hypoxia enhances human B19 erythrovirus gene expression in primary erythroid cells.

HIF-1alpha expression follows microvascular loss in advanced murine adriamycin nephrosis.

HIF and VEGF relationships in response to hypoxia and sciatic nerve stimulation in rat gastrocnemius.

Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2.

Central necrosis in isolated hypoxic human pancreatic islets: evidence for postisolation ischemia.

Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies.

NF-kappaB contributes to transcription of placenta growth factor and interacts with metal responsive transcription factor-1 in hypoxic human cells.

Preserved placental oxygenation and development during severe systemic hypoxia.

Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.

Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia.

Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions.

The effect of erythropoietin on gentamicin-induced auditory hair cell loss.

Sensing and responding to hypoxia via HIF in model invertebrates.

Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species.

Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration.

Regulating cellular oxygen sensing by hydroxylation.

Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosis.

Permanently increased conductance of the murine uterine arcade after the first pregnancy.

The yeast genome may harbor hypoxia response elements (HRE).

Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration.

Hypoxia-induced gene activity in disused oxidative muscle.

Excessive erythrocytosis does not elevate capillary oxygen delivery in subcutaneous mouse tissue.

Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin.

Simultaneous application of the vascular endothelial growth factor (VEGF) receptor inhibitor PTK787/ZK 222584 and ionizing radiation does not further reduce the growth of canine oral melanoma xenografts in nude mice.

Erythropoietin enhances immune responses in mice.

Enhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin.

Soluble erythropoietin receptor is present in the mouse brain and is required for the ventilatory acclimatization to hypoxia.

Acute and chronic exposure to hypoxia alters ventilatory pattern but not minute ventilation of mice overexpressing erythropoietin.

Oxygen-induced Regulation of Na/K ATPase in cerebellar granule cells.

Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligation.

Nociceptive tuning by stem cell factor/c-Kit signaling.

Novel three-dimensional analysis tool for vascular trees indicates complete micro-networks, not single capillaries, as the angiogenic endpoint in mice overexpressing human VEGF(165) in the brain.

Oxygen supply and retinal function: insights from a transgenic animal model.

Abortion in mice with excessive erythrocytosis is due to impaired arteriogenesis of the uterine arcade.

HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam.

Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.

Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice.

Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation.

Placental HIFs as markers of cerebral hypoxic distress in fetal mice.

Non-erythroid activities of erythropoietin: Functional effects on murine dendritic cells.

Erythropoietin protects from reperfusion-induced myocardial injury by enhancing coronary endothelial nitric oxide production.

Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin.

Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate.

Non-erythroid effects of erythropoietin: are neutrophils a target?

The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain.

Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain.

Erythropoietin activates nitric oxide synthase in murine erythrocytes.

Quantifying Western blots: pitfalls of densitometry.

Oxygen sensing and the activation of the hypoxia inducible factor 1 (HIF-1)--invited article.

Optimized surgical techniques and postoperative care improve survival rates and permit accurate telemetric recording in exercising mice.

Mast cells and macrophages in duodenal mucosa of mice overexpressing erythropoietin.

The impact of hypoxia on our body: from integrative physiology to human disease.

Erythropoietin modulates the neural control of hypoxic ventilation.

Erythropoietin but not VEGF has a protective effect on auditory hair cells in the inner ear.

The neuronal control of hypoxic ventilation: erythropoietin and sexual dimorphism.

Optimal hematocrit for maximal exercise performance in acute and chronic erythropoietin-treated mice.

Erythropoietin treatment leads to reduced blood glucose levels and body mass: insights from murine models.

Oxygen-induced regulation of the intracellular glutathione levels in erythrocytes.

Functional NMDA receptors in rat erythrocytes.

Macrophages as novel target cells for erythropoietin.

Erythropoietin: not just about erythropoiesis.

Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult.

Impaired ventilatory acclimatization to hypoxia in female mice overexpressing erythropoietin: unexpected deleterious effect of estradiol in carotid bodies.

Late-gestational systemic hypoxia leads to a similar early gene response in mouse placenta and developing brain.

Cdk5 interacts with Hif-1α in neurons: a new hypoxic signalling mechanism?

The role of excessive versus acute administration of erythropoietin in attenuating hepatic ischemia-reperfusion injury.

Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.

Erythropoietic and non-erythropoietic functions of erythropoietin in mouse models.

Interventricular heterogeneity in rat heart responses to hypoxia: the tuning of glucose metabolism, ion gradients, and function.

Respiratory plasticity in response to changes in oxygen supply and demand.

Hypoxia: adapting to high altitude by mutating EPAS-1, the gene encoding HIF-2α.

Oxygen 2011.

Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation.

Excessive erythrocytosis compromises the blood-endothelium interface in erythropoietin-overexpressing mice.

Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism.

Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?

Interaction of HIF and USF signaling pathways in human genes flanked by hypoxia-response elements and E-box palindromes.

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

The impact of hypoxia on cells, mice, and men.

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension.

Endogenous erythropoietin signaling facilitates skeletal muscle repair and recovery following pharmacologically induced damage.

Acute hypoxia modifies regulation of neuroglobin in the neonatal mouse brain.

Disturbed eating at high altitude: influence of food preferences, acute mountain sickness and satiation hormones.

Involvement of oxidative stress in hypoxia-induced blood-brain barrier breakdown.

Acute and chronic elevation of erythropoietin in the brain improves exercise performance in mice without inducing erythropoiesis.

Red blood cell volume and the capacity for exercise at moderate to high altitude.

S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity.

Cross talk between S-nitrosylation and S-glutathionylation in control of the Na,K-ATPase regulation in hypoxic heart.

The hypoxic placenta.

The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function.

Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells.

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Leh symposium 2012 and PVRI India annual symposium.

Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function.

Using plethysmography to determine erythropoietin's impact on neural control of ventilation.

Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation.

Erythrocytosis: the HIF pathway in control.

Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.

Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers.

Neuropilin-1 modulates vascular endothelial growth factor-induced poly(ADP-ribose)-polymerase leading to reduced cerebrovascular apoptosis.

Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development.

N-methyl-D-aspartate receptors in human erythroid precursor cells and in circulating red blood cells contribute to the intracellular calcium regulation.

Reduced insulin sensitivity as a marker for acute mountain sickness?

Restraint stress enhances arterial thrombosis in vivo--role of the sympathetic nervous system.

Decreased stability of erythroblastic islands in integrin β3-deficient mice.

Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism.

Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse.

Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway.

Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans.

Combination of erythropoietin and sildenafil can effectively attenuate hypoxia-induced pulmonary hypertension in mice.

Red blood cells of sickle cell disease patients exhibit abnormally high abundance of N-methyl D-aspartate receptors mediating excessive calcium uptake.

Mice over-expressing human erythropoietin indicate that erythropoietin enhances expression of its receptor via up-regulated Gata1 and Tal1.

Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation.

Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.

Erythropoietin directly stimulates osteoclast precursors and induces bone loss.

The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A.

Moderate hypothermia during ex vivo machine perfusion promotes recovery of hearts donated after cardiocirculatory death†.

The effects of short-term and long-term testosterone supplementation on blood viscosity and erythrocyte deformability in healthy adult mice.

Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.

Featured Article: microRNA-125a in pulmonary hypertension: Regulator of a proliferative phenotype of endothelial cells.

Differential responses of blood-brain barrier associated cells to hypoxia and ischemia: a comparative study.

PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.

Adaptation of iron requirement to hypoxic conditions at high altitude.

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.

Neuronal erythropoietin overexpression protects mice against age-related hearing loss (presbycusis).

Temporal Rac1 - HIF-1 crosstalk modulates hypoxic survival of aged neurons.

Increased EPO Levels Are Associated With Bone Loss in Mice Lacking PHD2 in EPO-Producing Cells.

Comparing the impact of an acute exercise bout on plasma amino acid composition, intraerythrocytic Ca(2+) handling, and red cell function in athletes and untrained subjects.

Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns.

Cardiac N-methyl D-aspartate Receptors as a Pharmacological Target.

Kinetic mRNA Profiling in a Rat Model of Left-Ventricular Hypertrophy Reveals Early Expression of Chemokines and Their Receptors.

Hypercapnic ventilatory response is decreased in a mouse model of excessive erythrocytosis.

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice.

Arginine-vasopressin marker copeptin is a sensitive plasma surrogate of hypoxic exposure.

Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation.

Protocol for a prospective, controlled, observational study to evaluate the influence of hypoxia on healthy volunteers and patients with inflammatory bowel disease: the Altitude IBD Study.

Aquaporin 1 controls the functional phenotype of pulmonary smooth muscle cells in hypoxia-induced pulmonary hypertension.

Erythropoietin enhances Kupffer cell number and activity in the challenged liver.

Biological aortic valve replacement: advantages and optimal indications of stentless compared to stented valve substitutes. A review.