Francisco Ciruela

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling.

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering.

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.

Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions.

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer.

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer.

Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation.

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders.

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors.

Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity.

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation.

Dimer-based model for heptaspanning membrane receptors.

Role of electrostatic interaction in receptor-receptor heteromerization.

Partners for adenosine A1 receptors.

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function.

Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers.

The two-state dimer receptor model: a general model for receptor dimers.

Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release.

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain.

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

Glutamate released by dendritic cells as a novel modulator of T cell activation.

Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor.

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.

Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.

The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor.

Functional relevance of neurotransmitter receptor heteromers in the central nervous system.

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration.

Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain.

Adenosine receptor heteromers and their integrative role in striatal function.

Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization.

Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum.

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

Fluorescence-based methods in the study of protein-protein interactions in living cells.

Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique.

Plasma membrane diffusion of G protein-coupled receptor oligomers.

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells.

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.

Adenosine receptors interacting proteins (ARIPs): Behind the biology of adenosine signaling.

A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R.

Impaired M(3) muscarinic acetylcholine receptor signal transduction through blockade of binding of multiple proteins to its third intracellular loop.

The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals.

The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization.

On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers.

Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.

An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A), dopamine D(2), cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors.

Lighting up multiprotein complexes: lessons from GPCR oligomerization.

The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor-receptor interactions.

G protein-coupled receptor oligomerization for what?

Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits.

Dopamine D2 and 5-hydroxytryptamine 5-HT(₂A) receptors assemble into functionally interacting heteromers.

Bioinformatics and mathematical modelling in the study of receptor-receptor interactions and receptor oligomerization: focus on adenosine receptors.

Characterization of the A2AR-D2R interface: focus on the role of the C-terminal tail and the transmembrane helices.

G-protein-coupled receptor heteromer dynamics.

Muscarinic receptor family interacting proteins: role in receptor function.

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

On the existence of a possible A2A-D2-β-Arrestin2 complex: A2A agonist modulation of D2 agonist-induced β-arrestin2 recruitment.

Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.

Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain.

Dopamine D4 receptor oligomerization--contribution to receptor biogenesis.

Caffeine improves attention deficit in neonatal 6-OHDA lesioned rats, an animal model of attention deficit hyperactivity disorder (ADHD).

Adenosine receptors.

Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family.

Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.

Moonlighting characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration.

Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands.

G protein-coupled receptors interacting proteins: towards the druggable interactome.

An update on adenosine A2A receptors as drug target in Parkinson's disease.

Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms.

GABAB receptors-associated proteins: potential drug targets in neurological disorders?

Fibroblast growth factor receptor 1- 5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity.

Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation.

Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice.

A modification of the split-tobacco etch virus method for monitoring interactions between membrane proteins in mammalian cells.

On the role of volume transmission and receptor-receptor interactions in social behaviour: focus on central catecholamine and oxytocin neurons.

The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.

G protein-coupled receptor oligomerization and brain integration: focus on adenosinergic transmission.

Extrasynaptic neurotransmission in the modulation of brain function. Focus on the striatal neuronal-glial networks.

Fluorescence resonance energy transfer-based technologies in the study of protein-protein interactions at the cell surface.

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression.

Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R.

On the existence and function of galanin receptor heteromers in the central nervous system.

G protein-coupled receptor heterodimerization in the brain.

The Parkinson's disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.

A new interpretative paradigm for Conformational Protein Diseases.

Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels.

The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells.

Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework.

Preface. In cells.

Guanosine behind the scene.

β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.

Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field.

Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor.

Striatal adenosine A2A receptor expression is controlled by S-adenosyl-L-methionine-mediated methylation.

Portraying G protein-coupled receptors with fluorescent ligands.

Deciphering G protein-coupled receptor biology with fluorescence-based methods.

Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand.

Uncovering caffeine's adenosine A2A receptor inverse agonism in experimental parkinsonism.

Coassembly and coupling of SK2 channels and mGlu5 receptors.

Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in rats.

Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system.

Adenosine A1 receptor activation modulates N-methyl-d-aspartate (NMDA) preconditioning phenotype in the brain.

GPCR oligomerization analysis by means of BRET and dFRAP.

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system.

Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.

Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.

Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression.

Visualizing G Protein-Coupled Receptor-Receptor Interactions in Brain Using Proximity Ligation In Situ Assay.

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells.

Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors.

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

Genetic blockade of adenosine A2A receptors induces cognitive impairments and anatomical changes related to psychotic symptoms in mice.

The Exonuclease Trex2 Shapes Psoriatic Phenotype.

The Guanine-Based Purinergic System: The Tale of An Orphan Neuromodulation.

Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes.

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor.

Exploring Drug-Receptor Interaction Kinetics: Lessons from a Sigma-1 Receptor Transmembrane Biosensor.

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals.

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.