Ulrich Dirnagl

Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura?

Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro.

Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice.

Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent.

Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia.

Isoflurane induced prolonged protection against cerebral ischemia in mice: a redox sensitive mechanism?

Triptans reduce the inflammatory response in bacterial meningitis.

Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition.

Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats.

Focal laminar cortical MR signal abnormalities after subarachnoid hemorrhage.

Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model.

Withdrawal of statin treatment abrogates stroke protection in mice.

Ischemia and stroke.

Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo.

Ischemic tolerance and endogenous neuroprotection.

Neuronal activity-induced changes of local cerebral microvascular blood oxygenation in the rat: effect of systemic hyperoxia or hypoxia.

Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation.

Improved protocol for SAGE tag-to-gene allocation.

Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin.

Bone marrow-derived cells expressing green fluorescent protein under the control of the glial fibrillary acidic protein promoter do not differentiate into astrocytes in vitro and in vivo.

Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation.

Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels.

Mechanisms of stroke protection by physical activity.

Ischemia triggered by spreading neuronal activation is induced by endothelin-1 and hemoglobin in the subarachnoid space.

A fluorescence-based method to assess plasma protein extravasation in rat dura mater using confocal laser scanning microscopy.

Selective neuronal vulnerability following mild focal brain ischemia in the mouse.

ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo.

Dysexecutive syndrome after mild cerebral ischemia? Mice learn normally but have deficits in strategy switching.

Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke.

Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization.

HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis.

Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo.

Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis.

Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.

Pathophysiology of stroke: lessons from animal models.

Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury.

Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia.

Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones.

Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning.

Role of glial cells in cerebral ischemia.

Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.

Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO.

Central nervous system injury-induced immune deficiency syndrome.

Partial antagonistic effect of adenosine on inverse coupling between spreading neuronal activation and cerebral blood flow in rats.

Nitric oxide modulates calcium entry through P/Q-type calcium channels and N-methyl-d-aspartate receptors in rat cortical neurons.

Effects of parecoxib on plasma protein extravasation and c-fos expression in the rat.

Bench to bedside: the quest for quality in experimental stroke research.

Improved reperfusion and neuroprotection by creatine in a mouse model of stroke.

Stroke research priorities for the next decade--A representative view of the European scientific community.

Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP.

Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia.

Noninvasive near-infrared imaging of fluorochromes within the brain of live mice: an in vivo phantom study.

Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging.

Roller culture of free-floating retinal slices: a new system of organotypic cultures of adult rat retina.

Functional imaging with laser speckle contrast analysis: vascular compartment analysis and correlation with laser Doppler flowmetry and somatosensory evoked potentials.

Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow.

Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis.

Stroke-induced immunodepression: experimental evidence and clinical relevance.

Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures.

Phosphatidylinositol 3-Akt-kinase-dependent phosphorylation of p21(Waf1/Cip1) as a novel mechanism of neuroprotection by glucocorticoids.

Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.

Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke.

Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral ischemia in mice.

Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans.

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

Doxorubicin induces biphasic neurotoxicity to rat cortical neurons.

Improving outcome after stroke: overcoming the translational roadblock.

Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex.

Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen.

Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning?

Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial.

5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures.

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality.

In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody.

Good laboratory practice: preventing introduction of bias at the bench.

The ischemic cascade and mediators of ischemic injury.

Reprint: Good laboratory practice: preventing introduction of bias at the bench.

Fluorescence tomography technique optimized for noninvasive imaging of the mouse brain.

Reprint: Good laboratory practice: preventing introduction of bias at the bench.

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use.

Effects of the PDE5-inhibitor vardenafil in a mouse stroke model.

In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia.

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage.

Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice.

Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice.

Pharmacological uncoupling of activation induced increases in CBF and CMRO2.

Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia.

Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation.

If you have the science, we have the journal!

Statistics in experimental cerebrovascular research-comparison of two groups with a continuous outcome variable.

Membrane attack complex inhibitor CD59a protects against focal cerebral ischemia in mice.

Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats.

CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia.

Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable.

Fighting publication bias: introducing the Negative Results section.

Oxygen maps in the brain.

Determination of the brain-blood partition coefficient for water in mice using MRI.

Pathophysiological interference with neurovascular coupling - when imaging based on hemoglobin might go blind.

Effect of 3,4-methylenedioxyamphetamine on dendritic spine dynamics in rat neocortical neurons--involvement of heat shock protein 27.

Immune responses after acute ischemic stroke or myocardial infarction.

Hypothermia for Stroke: call to action 2010.

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain.

Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism.

Improving the quality of biomedical research: guidelines for reporting experiments involving animals.

Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining.

Non-invasive surface-stripping for epifluorescence small animal imaging.

IL-1β stimulates COX-2 dependent PGE₂ synthesis and CGRP release in rat trigeminal ganglia cells.

Non-resolving aspects of acute inflammation after spinal cord injury (SCI): indices and resolution plateau.

Stroke and the immune system: from pathophysiology to new therapeutic strategies.

Rotation of Editorial Board Members and new publication formats.

Acute pathophysiological processes after ischaemic and traumatic brain injury.

Protective conditioning of the brain: expressway or roadblock?

SUMO2/3 conjugation is an endogenous neuroprotective mechanism.

Body weight after stroke: lessons from the obesity paradox.

Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives.

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.