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Center for Stroke Research Berlin, Charité Universitätsmedizin

2 ARTICLES PUBLISHED IN JoVE

Medicine

Modeling Stroke in Mice - Middle Cerebral Artery Occlusion with the Filament Model

Odilo Engel¹, Sabine Kolodziej¹, Ulrich Dirnagl¹, Vincent Prinz¹

¹Department for Experimental Neurology, Center for Stroke Research Berlin, Charité Universitätsmedizin

Filamentous occlusion of the Middle cerebral artery is a common model for studying ischemic stroke in mice.

Neuroscience

Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice

Simon H. Bayerl¹, Melina Nieminen-Kelhä¹, Thomas Broggini², Peter Vajkoczy¹, Vincent Prinz¹

¹Department of Neurosurgery and Center for Stroke-research Berlin (CSB), Charité-Universitätsmedizin, ²Department of Physics, University of California San Diego

Surgical occlusion of a distal middle cerebral artery branch (MCAo) is a frequently used model in experimental stroke research. This manuscript describes the basic technique of permanent MCAo, combined with the insertion of a lateral cranial window, which offers the opportunity for longitudinal intravital microscopy in mice.