Brian N Chorley

Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C{delta}-mediated mechanism.

(R)-albuterol elicits antiinflammatory effects in human airway epithelial cells via iNOS.

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro.

Identification of polymorphic antioxidant response elements in the human genome.

Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies.

Probing the functional impact of sequence variation on p53-DNA interactions using a novel microsphere assay for protein-DNA binding with human cell extracts.

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

Novel hematopoietic target genes in the NRF2-mediated transcriptional pathway.

Comparative time course profiles of phthalate stereoisomers in mice.

Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice.

Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action.

Tipping the Balance: Hepatotoxicity and the 4 Apical Key Events of Hepatic Steatosis.

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders.

Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells.

MicroRNA Biomarkers of Toxicity in Biological Matrices.

Editor's Highlight: Dose-Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples.