K. Peter R. Nilsson

Chip and solution detection of DNA hybridization using a luminescent zwitterionic polythiophene derivative.

Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative.

Twisting macromolecular chains: self-assembly of a chiral supermolecule from nonchiral polythiophene polyanions and random-coil synthetic peptides.

Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibril formation at acidic pH.

Conjugated polyelectrolytes: conformation-sensitive optical probes for detection of amyloid fibril formation.

Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.

Surface energy modified chips for detection of conformational states and enzymatic activity in biomolecules.

Conjugated polyelectrolytes--conformation-sensitive optical probes for staining and characterization of amyloid deposits.

Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes.

Studies of luminescent conjugated polythiophene derivatives: enhanced spectral discrimination of protein conformational states.

Prion strain discrimination using luminescent conjugated polymers.

A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis.

Small organic probes as amyloid specific ligands--past and recent molecular scaffolds.

Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses.

Fluorescent oligo and poly-thiophenes and their utilization for recording biological events of diverse origin-when organic chemistry meets biology.

Amyloid fibrils of human prion protein are spun and woven from morphologically disordered aggregates.

Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy.

Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.

Conjugated polymers for enhanced bioimaging.

A molecular switch controls interspecies prion disease transmission in mice.

Two amyloid States of the prion protein display significantly different folding patterns.

A fluorescent pentameric thiophene derivative detects in vitro-formed prefibrillar protein aggregates.

Spatially controlled amyloid reactions using organic electronics.

Prion strain interactions are highly selective.

Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.

Tracking protein aggregate interactions.

Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation.

Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.

Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein.

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates.

Cell interaction study of amyloid by using luminescent conjugated polythiophene: implication that amyloid cytotoxicity is correlated with prolonged cellular binding.

Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.

Nanoscopic and photonic ultrastructural characterization of two distinct insulin amyloid states.

Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants.

Structure of the β2-α2 loop and interspecies prion transmission.

Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates.

A pentameric luminescent-conjugated oligothiophene for optical imaging of in vitro-formed amyloid fibrils and protein aggregates in tissue sections.

Derivatization of a bioorthogonal protected trisaccharide linker-toward multimodal tools for chemical biology.

Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.

Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates.

Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.

Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes.

Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies.

Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand.

Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.

Superresolution imaging of amyloid fibrils with binding-activated probes.

Defining the conformational features of anchorless, poorly neuroinvasive prions.

The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates.

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice.

Cell type related differences in staining with pentameric thiophene derivatives.

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen.

An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates.

Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts.

Aβ seeds resist inactivation by formaldehyde.

Toward a molecular understanding of the detection of amyloid proteins with flexible conjugated oligothiophenes.

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands.

Differential vital staining of normal fibroblasts and melanoma cells by an anionic conjugated polyelectrolyte.

Sensitive and rapid assessment of amyloid by oligothiophene fluorescence in subcutaneous fat tissue.

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.

Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates.

The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice.

Structure-based drug design identifies polythiophenes as antiprion compounds.

Pathological, biochemical, and biophysical characteristics of the transthyretin variant Y114H (p.Y134H) explain its very mild clinical phenotype.

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

An imidazole functionalized pentameric thiophene displays different staining patterns in normal and malignant cells.

Protein aggregation as an antibiotic design strategy.

Establishing the fluorescent amyloid ligand h-FTAA for studying human tissues with systemic and localized amyloid.

Labeling nanoparticles: Dye leakage and altered cellular uptake.

(11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates.

Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model.

Nondestructive, real-time determination and visualization of cellulose, hemicellulose and lignin by luminescent oligothiophenes.

Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ.

De novo design of a biologically active amyloid.

Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation.

In vivo polymerization and manufacturing of wires and supercapacitors in plants.

Post-translational modifications in PrP expand the conformational diversity of prions in vivo.

Specific Imaging of Intracellular Lipid Droplets Using a Benzothiadiazole Derivative with Solvatochromic Properties.

Establishing and validating the fluorescent amyloid ligand h-FTAA (heptamer formyl thiophene acetic acid) to identify transthyretin amyloid deposits in carpal tunnel syndrome.

Seed-dependent templating of murine AA amyloidosis.

Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells.

Real-time optotracing of curli and cellulose in live Salmonella biofilms using luminescent oligothiophenes.

Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets.