K. Peter R. Nilsson

IFM-Department of Chemistry, linköping university

Research Area

Biochemistry

Biography

K. Peter R. Nilsson has not added Biography.
If you are K. Peter R. Nilsson and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2017

Other Publications

Article	Year
Chip and solution detection of DNA hybridization using a luminescent zwitterionic polythiophene derivative. Nature materials\| PubMed ID: 12754497	2003
Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12928490	2003
Twisting macromolecular chains: self-assembly of a chiral supermolecule from nonchiral polythiophene polyanions and random-coil synthetic peptides. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15280547	2004
Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibril formation at acidic pH. Journal of the American Chemical Society\| PubMed ID: 15713111	2005
Conjugated polyelectrolytes: conformation-sensitive optical probes for detection of amyloid fibril formation. Biochemistry\| PubMed ID: 15751948	2005
Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers\| PubMed ID: 15931669	2005
Surface energy modified chips for detection of conformational states and enzymatic activity in biomolecules. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 16489808	2006
Conjugated polyelectrolytes--conformation-sensitive optical probes for staining and characterization of amyloid deposits. Chembiochem : a European journal of chemical biology\| PubMed ID: 16729336	2006
Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes. ACS chemical biology\| PubMed ID: 17672509	2007
Studies of luminescent conjugated polythiophene derivatives: enhanced spectral discrimination of protein conformational states. Bioconjugate chemistry\| PubMed ID: 17939727	2007
Prion strain discrimination using luminescent conjugated polymers. Nature methods\| PubMed ID: 18026110	2007
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiology of aging\| PubMed ID: 18192084	2009
De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19073920	2009
Small organic probes as amyloid specific ligands--past and recent molecular scaffolds. FEBS letters\| PubMed ID: 19376114	2009
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (New York, N.Y.)\| PubMed ID: 19541956	2009
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS chemical biology\| PubMed ID: 19624097	2009
Fluorescent oligo and poly-thiophenes and their utilization for recording biological events of diverse origin-when organic chemistry meets biology. Journal of chemical biology\| PubMed ID: 19649670	2009
Amyloid fibrils of human prion protein are spun and woven from morphologically disordered aggregates. Prion\| PubMed ID: 19923901	2009
Structural typing of systemic amyloidoses by luminescent-conjugated polymer spectroscopy. The American journal of pathology\| PubMed ID: 20035056	2010
Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses. Nature protocols\| PubMed ID: 20431539	2010
Conjugated polymers for enhanced bioimaging. Biochimica et biophysica acta\| PubMed ID: 20471455	2011
A molecular switch controls interspecies prion disease transmission in mice. The Journal of clinical investigation\| PubMed ID: 20551516	2010
Two amyloid States of the prion protein display significantly different folding patterns. Journal of molecular biology\| PubMed ID: 20553730	2010
A fluorescent pentameric thiophene derivative detects in vitro-formed prefibrillar protein aggregates. Biochemistry\| PubMed ID: 20604540	2010
Spatially controlled amyloid reactions using organic electronics. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20814927	2010
Prion strain interactions are highly selective. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20826672	2010
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease. The American journal of pathology\| PubMed ID: 21514441	2011
Tracking protein aggregate interactions. Prion\| PubMed ID: 21597336	2011
Drosophila melanogaster as a model system for studies of islet amyloid polypeptide aggregation. PloS one\| PubMed ID: 21695120	2011
Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions. Gastroenterology\| PubMed ID: 21699779	2011
Spongiform encephalopathy in transgenic mice expressing a point mutation in the Î²2-Î±2 loop of the prion protein. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21957246	2011
Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates. Organic & biomolecular chemistry\| PubMed ID: 22051883	2011
Cell interaction study of amyloid by using luminescent conjugated polythiophene: implication that amyloid cytotoxicity is correlated with prolonged cellular binding. Chembiochem : a European journal of chemical biology\| PubMed ID: 22262644	2012
Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PloS one\| PubMed ID: 22348084	2012
Nanoscopic and photonic ultrastructural characterization of two distinct insulin amyloid states. International journal of molecular sciences\| PubMed ID: 22408402	2012
Identification of distinct physiochemical properties of toxic prefibrillar species formed by Aβ peptide variants. Biochemical and biophysical research communications\| PubMed ID: 22475489	2012
Structure of the β2-α2 loop and interspecies prion transmission. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22490928	2012
Polythiophenes inhibit prion propagation by stabilizing prion protein (PrP) aggregates. The Journal of biological chemistry\| PubMed ID: 22493452	2012
A pentameric luminescent-conjugated oligothiophene for optical imaging of in vitro-formed amyloid fibrils and protein aggregates in tissue sections. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22528107	2012
Derivatization of a bioorthogonal protected trisaccharide linker-toward multimodal tools for chemical biology. Bioconjugate chemistry\| PubMed ID: 22568531	2012
Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway. The Journal of biological chemistry\| PubMed ID: 22669942	2012
Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates. Biochemical Society transactions\| PubMed ID: 22817720	2012
Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imag... Acta neuropathologica\| PubMed ID: 22996963	2013
Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes. The American journal of pathology\| PubMed ID: 23041059	2012
Luminescent conjugated oligothiophenes for sensitive fluorescent assignment of protein inclusion bodies. Chembiochem : a European journal of chemical biology\| PubMed ID: 23450708	2013
Enhanced fluorescent assignment of protein aggregates by an oligothiophene-porphyrin-based amyloid ligand. Macromolecular rapid communications\| PubMed ID: 23468206	2013
Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits. ACS chemical biology\| PubMed ID: 23521783	2013
Superresolution imaging of amyloid fibrils with binding-activated probes. ACS chemical neuroscience\| PubMed ID: 23594172	2013
Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS pathogens\| PubMed ID: 23637596	2013
The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein ag... Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23780508	2013
Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice. EMBO reports\| PubMed ID: 23999102	2013
Cell type related differences in staining with pentameric thiophene derivatives. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 24500794	2014
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nature communications\| PubMed ID: 24691351	2014
An azide functionalized oligothiophene ligand--a versatile tool for multimodal detection of disease associated protein aggregates. Biosensors & bioelectronics\| PubMed ID: 25089818	2015
Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 25111601	2014
Aβ seeds resist inactivation by formaldehyde. Acta neuropathologica\| PubMed ID: 25193240	2014
Toward a molecular understanding of the detection of amyloid proteins with flexible conjugated oligothiophenes. The journal of physical chemistry. A\| PubMed ID: 25247879	2014
Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion\| PubMed ID: 25495506	2014
Differential vital staining of normal fibroblasts and melanoma cells by an anionic conjugated polyelectrolyte. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 25605326	2015
Sensitive and rapid assessment of amyloid by oligothiophene fluorescence in subcutaneous fat tissue. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 25847117	2015
Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice. Neurobiology of aging\| PubMed ID: 25911278	2015
Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26013403	2015
The fluorescent pentameric oligothiophene pFTAA identifies filamentous tau in live neurons cultured from adult P301S tau mice. Frontiers in neuroscience\| PubMed ID: 26074756	2015
Structure-based drug design identifies polythiophenes as antiprion compounds. Science translational medicine\| PubMed ID: 26246168	2015
Pathological, biochemical, and biophysical characteristics of the transthyretin variant Y114H (p.Y134H) explain its very mild clinical phenotype. Journal of the peripheral nervous system : JPNS\| PubMed ID: 26306725	2015
A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26388448	2015
An imidazole functionalized pentameric thiophene displays different staining patterns in normal and malignant cells. Frontiers in chemistry\| PubMed ID: 26501054	2015
Protein aggregation as an antibiotic design strategy. Molecular microbiology\| PubMed ID: 26559925	2016
Establishing the fluorescent amyloid ligand h-FTAA for studying human tissues with systemic and localized amyloid. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 26987044	2016
Labeling nanoparticles: Dye leakage and altered cellular uptake. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 27077940	2017
(11)C and (18)F Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates. ACS medicinal chemistry letters\| PubMed ID: 27096043	2016
Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27147660	2016
Nondestructive, real-time determination and visualization of cellulose, hemicellulose and lignin by luminescent oligothiophenes. Scientific reports\| PubMed ID: 27759105	2016
Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 27767229	2016
De novo design of a biologically active amyloid. Science (New York, N.Y.)\| PubMed ID: 27846578	2016
Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation. Frontiers in chemistry\| PubMed ID: 27921029	2016
In vivo polymerization and manufacturing of wires and supercapacitors in plants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28242683	2017
Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Scientific reports\| PubMed ID: 28272426	2017
Specific Imaging of Intracellular Lipid Droplets Using a Benzothiadiazole Derivative with Solvatochromic Properties. Bioconjugate chemistry\| PubMed ID: 28402621	2017
Establishing and validating the fluorescent amyloid ligand h-FTAA (heptamer formyl thiophene acetic acid) to identify transthyretin amyloid deposits in carpal tunnel syndrome. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 28434259	2017
Seed-dependent templating of murine AA amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 28434369	2017
Non-fused Phospholes as Fluorescent Probes for Imaging of Lipid Droplets in Living Cells. Frontiers in chemistry\| PubMed ID: 28487854	2017
Real-time optotracing of curli and cellulose in live Salmonella biofilms using luminescent oligothiophenes. NPJ biofilms and microbiomes\| PubMed ID: 28721253	2016
Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets. Endocrine connections\| PubMed ID: 28790139	2017