Connie Darmanin

Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.

Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase.

Structure-based design of inhibitors of human L-xylulose reductase modelled into the active site of the enzyme.

Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.

Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors.

Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry.

High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.

Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

Characterisation of an autoreactive conformational epitope on GAD65 recognised by the human monoclonal antibody b78 using a combination of phage display, in vitro mutagenesis and molecular modelling.

Discovery of potential sorbitol dehydrogenase inhibitors from virtual screening.

Hematin-hematin self-association states involved in the formation and reactivity of the malaria parasite pigment, hemozoin.

High-throughput production and structural characterization of libraries of self-assembly lipidic cubic phase materials.

Uptake of the butyrate receptors, GPR41 and GPR43, in lipidic bicontinuous cubic phases suitable for in meso crystallization.

Protein crystal screening and characterization for serial femtosecond nanocrystallography.

X-ray laser-induced electron dynamics observed by femtosecond diffraction from nanocrystals of Buckminsterfullerene.